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Overrunning in clinical trials: some thoughts from a methodological review

BACKGROUND: In sequential and adaptive trials, the delay that happens after the trial is stopped, by a predetermined stopping criterion, takes the name of overrunning. Overrunning consists of extra data, collected by investigators while awaiting results of the interim analysis (IA). The inclusion of...

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Detalles Bibliográficos
Autores principales:	Baldi, Ileana, Azzolina, Danila, Soriani, Nicola, Barbetta, Beatrice, Vaghi, Paola, Giacovelli, Giampaolo, Berchialla, Paola, Gregori, Dario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374901/ https://www.ncbi.nlm.nih.gov/pubmed/32693832 http://dx.doi.org/10.1186/s13063-020-04526-5

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