Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats

BACKGROUND: Microglia, the principal sentinel immune cells of the central nervous system (CNS), play an extensively vital role in neuroinflammation and perioperative neurocognitive disorders (PND). Histamine, a potent mediator of inflammation, can both promote and prevent microglia-related neuroinfl...

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Detalles Bibliográficos
Autores principales: Chen, Yi-Nan, Sha, Huan-Huan, Wang, Yi-Wei, Zhou, Qin, Bhuiyan, Piplu, Li, Na-Na, Qian, Yan-Ning, Dong, Hong-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374916/
https://www.ncbi.nlm.nih.gov/pubmed/32698899
http://dx.doi.org/10.1186/s12974-020-01886-2

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