Cargando…

Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site

BACKGROUND: The binding of HIV-1 Envelope glycoproteins (Env) to host receptor CD4 exposes vulnerable conserved epitopes within the co-receptor binding site (CoRBS) which are required for the engagement of either CCR5 or CXCR4 co-receptor to allow HIV-1 entry. Antibodies against this region have bee...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tolbert, William D., Sherburn, Rebekah, Gohain, Neelakshi, Ding, Shilei, Flinko, Robin, Orlandi, Chiara, Ray, Krishanu, Finzi, Andrés, Lewis, George K., Pazgier, Marzena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374964/ https://www.ncbi.nlm.nih.gov/pubmed/32693837 http://dx.doi.org/10.1186/s12915-020-00819-y

Ejemplares similares

Induction of Fc-Mediated Effector Functions Against a Stabilized Inner Domain of HIV-1 gp120 Designed to Selectively Harbor the A32 Epitope Region
por: Visciano, Maria L., et al.
Publicado: (2019)

Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques
por: Tolbert, William D., et al.
Publicado: (2022)

Effects of gp120 Inner Domain (ID2) Immunogen Doses on Elicitation of Anti-HIV-1 Functional Fc-Effector Response to C1/C2 (Cluster A) Epitopes in Mice
por: Sherburn, Rebekah, et al.
Publicado: (2020)

Molecular basis for epitope recognition by non-neutralizing anti-gp41 antibody F240
por: Gohain, Neelakshi, et al.
Publicado: (2016)

Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity
por: Tolbert, William D., et al.
Publicado: (2019)

Incorporating the Cluster A and V1V2 Targets into a Minimal Structural Unit of the HIV-1 Envelope to Elicit a Cross-Clade Response with Potent Fc-Effector Functions
por: Sherburn, Rebekah, et al.
Publicado: (2021)

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities
por: Chen, Yaozong, et al.
Publicado: (2021)

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities
por: Chen, Yaozong, et al.
Publicado: (2022)

Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial
por: Tolbert, William D., et al.
Publicado: (2020)

Erratum for Tolbert et al., “Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial”
por: Tolbert, William D., et al.
Publicado: (2021)

Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells
por: Richard, Jonathan, et al.
Publicado: (2021)

Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region
por: Tolbert, William D., et al.
Publicado: (2016)

Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression
por: Li, Xiang, et al.
Publicado: (2021)

Piperidine CD4-mimetic compounds expose vulnerable Env epitopes sensitizing HIV-1-infected cells to ADCC
por: Ding, Shilei, et al.
Publicado: (2023)

Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC
por: Ding, Shilei, et al.
Publicado: (2023)

Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design
por: Li, Xiang, et al.
Publicado: (2018)

Concurrent Exposure of Neutralizing and Non-neutralizing Epitopes on a Single HIV-1 Envelope Structure
por: Ray, Krishanu, et al.
Publicado: (2019)

HIV-1 Vpu restricts Fc-mediated effector functions in vivo
por: Prévost, Jérémie, et al.
Publicado: (2022)

Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s
por: Tolbert, William D., et al.
Publicado: (2022)

Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins
por: Richard, Jonathan, et al.
Publicado: (2016)

Stoichiometric Analyses of Soluble CD4 to Native-like HIV-1 Envelope by Single-Molecule Fluorescence Spectroscopy
por: Agrawal, Parul, et al.
Publicado: (2019)

Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1
por: Lewis, George K., et al.
Publicado: (2015)

A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection
por: Beaudoin-Bussières, Guillaume, et al.
Publicado: (2022)

The molecular basis of the neutralization breadth of the RBD-specific antibody CoV11
por: Tolbert, William D., et al.
Publicado: (2023)

Coordinated Fc-effector and neutralization functions in HIV-infected children define a window of opportunity for HIV vaccination
por: Nduati, Eunice W., et al.
Publicado: (2021)

A new cell line for high throughput HIV-specific antibody-dependent cellular cytotoxicity (ADCC) and cell-to-cell virus transmission studies
por: Orlandi, Chiara, et al.
Publicado: (2016)

Fc-Engineered Antibodies with Enhanced Fc-Effector Function for the Treatment of B-Cell Malignancies
por: van der Horst, Hilma J., et al.
Publicado: (2020)

Near-Pan-neutralizing, Plasma Deconvoluted Antibody N49P6 Mimics Host Receptor CD4 in Its Quaternary Interactions with the HIV-1 Envelope Trimer
por: Tolbert, William D., et al.
Publicado: (2021)

The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site
por: Prévost, Jérémie, et al.
Publicado: (2020)

Vector induced skewing of antibody Fc-effector functions
por: Chung, A, et al.
Publicado: (2012)

Antigen-dependent modulation of immune responses to antigen-Fc fusion proteins by Fc-effector functions
por: Richel, Elie, et al.
Publicado: (2023)

The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice
por: Ullah, Irfan, et al.
Publicado: (2022)

Polymeric human Fc-fusion proteins with modified effector functions
por: Mekhaiel, David N. A., et al.
Publicado: (2011)

IgG Fc engineering to modulate antibody effector functions
por: Wang, Xinhua, et al.
Publicado: (2017)

Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function
por: Escobar-Cabrera, Eric, et al.
Publicado: (2017)

Engineered Fc-glycosylation switch to eliminate antibody effector function
por: Zhou, Qun, et al.
Publicado: (2020)

Fc-engineered antibodies with immune effector functions completely abolished
por: Wilkinson, Ian, et al.
Publicado: (2021)

Rule-governed behavior : cognition, contingencies, and instructional control /
Publicado: (1989)

Mouse α-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt
por: Wang, Qingxia, et al.
Publicado: (2022)

Defining the kinetochore’s rules of engagement
por: Short, Ben
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_lvsr2o7m4jov6kbpbcgc4fmvqf