METTL1-mediated m(7)G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development

BACKGROUND: 7-Methylguanosine (m(7)G) is one of the most conserved modifications in nucleosides within tRNAs and rRNAs. It plays essential roles in the regulation of mRNA export, splicing, and translation. Recent studies highlighted the importance of METTL1-mediated m(7)G tRNA methylome in the self-...

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Detalles Bibliográficos
Autores principales: Deng, Yujie, Zhou, Zhongyang, Ji, Weidong, Lin, Shuibin, Wang, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374972/
https://www.ncbi.nlm.nih.gov/pubmed/32698871
http://dx.doi.org/10.1186/s13287-020-01814-4

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