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The μ‐opioid receptor gene A118G polymorphism is associated with insecure attachment in children with disruptive mood regulation disorder and their mothers

BACKGROUND: The A118G single nucleotide polymorphism (SNP) of the μ‐opioid receptor gene, with high expression of the A allele and low expression of the G allele, has been associated with emotional/behavioral dysregulation and depressive disorders and is recognized as a mediator of affiliative behav...

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Autores principales: Cimino, Silvia, Carola, Valeria, Cerniglia, Luca, Bussone, Silvia, Bevilacqua, Arturo, Tambelli, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375094/
https://www.ncbi.nlm.nih.gov/pubmed/32424914
http://dx.doi.org/10.1002/brb3.1659
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author Cimino, Silvia
Carola, Valeria
Cerniglia, Luca
Bussone, Silvia
Bevilacqua, Arturo
Tambelli, Renata
author_facet Cimino, Silvia
Carola, Valeria
Cerniglia, Luca
Bussone, Silvia
Bevilacqua, Arturo
Tambelli, Renata
author_sort Cimino, Silvia
collection PubMed
description BACKGROUND: The A118G single nucleotide polymorphism (SNP) of the μ‐opioid receptor gene, with high expression of the A allele and low expression of the G allele, has been associated with emotional/behavioral dysregulation and depressive disorders and is recognized as a mediator of affiliative behavior. No study has thus far investigated this SNP in school‐age children with disruptive mood regulation disorder (DMDD). This study compared a sample of healthy children and their mothers with a sample of children with DMDD and their mothers, evaluating whether insecure attachment and psychopathological symptoms are associated with A allele‐ or G allele‐carrying mothers and children and whether caregiving capacities are associated with A allele‐ or G allele‐carrying mothers. METHODS: For evaluation of their psychopathological symptoms and attachment styles, mothers filled out the CBCL/6‐18, the SCL‐90‐R, and the ECR. To evaluate the types of relationship children were experiencing with their mothers, children filled out the ECR‐revised child version and the PBI. Genotypic analyses were conducted on DNA samples obtained by buccal swabbing from children and mothers. RESULTS: An insecure attachment style was more frequent in mothers and children carrying the G allele (G/G + A/G genotypes). In the clinical sample, G allele‐carrying children scored higher than homozygous A/A ones on the subscales of Withdrawal and Conduct Problems. G‐carrying mothers showed higher interpersonal sensitivity, depression, hostility, and paranoid ideation and provided less care than A/A mothers. CONCLUSIONS: This study offers new insights into the associations between the A118G SNP of the μ‐opioid receptor gene and emotional/behavioral functioning, attachment style in children, and psychopathology and caregiving ability in mothers.
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spelling pubmed-73750942020-07-22 The μ‐opioid receptor gene A118G polymorphism is associated with insecure attachment in children with disruptive mood regulation disorder and their mothers Cimino, Silvia Carola, Valeria Cerniglia, Luca Bussone, Silvia Bevilacqua, Arturo Tambelli, Renata Brain Behav Original Research BACKGROUND: The A118G single nucleotide polymorphism (SNP) of the μ‐opioid receptor gene, with high expression of the A allele and low expression of the G allele, has been associated with emotional/behavioral dysregulation and depressive disorders and is recognized as a mediator of affiliative behavior. No study has thus far investigated this SNP in school‐age children with disruptive mood regulation disorder (DMDD). This study compared a sample of healthy children and their mothers with a sample of children with DMDD and their mothers, evaluating whether insecure attachment and psychopathological symptoms are associated with A allele‐ or G allele‐carrying mothers and children and whether caregiving capacities are associated with A allele‐ or G allele‐carrying mothers. METHODS: For evaluation of their psychopathological symptoms and attachment styles, mothers filled out the CBCL/6‐18, the SCL‐90‐R, and the ECR. To evaluate the types of relationship children were experiencing with their mothers, children filled out the ECR‐revised child version and the PBI. Genotypic analyses were conducted on DNA samples obtained by buccal swabbing from children and mothers. RESULTS: An insecure attachment style was more frequent in mothers and children carrying the G allele (G/G + A/G genotypes). In the clinical sample, G allele‐carrying children scored higher than homozygous A/A ones on the subscales of Withdrawal and Conduct Problems. G‐carrying mothers showed higher interpersonal sensitivity, depression, hostility, and paranoid ideation and provided less care than A/A mothers. CONCLUSIONS: This study offers new insights into the associations between the A118G SNP of the μ‐opioid receptor gene and emotional/behavioral functioning, attachment style in children, and psychopathology and caregiving ability in mothers. John Wiley and Sons Inc. 2020-05-18 /pmc/articles/PMC7375094/ /pubmed/32424914 http://dx.doi.org/10.1002/brb3.1659 Text en © 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Cimino, Silvia
Carola, Valeria
Cerniglia, Luca
Bussone, Silvia
Bevilacqua, Arturo
Tambelli, Renata
The μ‐opioid receptor gene A118G polymorphism is associated with insecure attachment in children with disruptive mood regulation disorder and their mothers
title The μ‐opioid receptor gene A118G polymorphism is associated with insecure attachment in children with disruptive mood regulation disorder and their mothers
title_full The μ‐opioid receptor gene A118G polymorphism is associated with insecure attachment in children with disruptive mood regulation disorder and their mothers
title_fullStr The μ‐opioid receptor gene A118G polymorphism is associated with insecure attachment in children with disruptive mood regulation disorder and their mothers
title_full_unstemmed The μ‐opioid receptor gene A118G polymorphism is associated with insecure attachment in children with disruptive mood regulation disorder and their mothers
title_short The μ‐opioid receptor gene A118G polymorphism is associated with insecure attachment in children with disruptive mood regulation disorder and their mothers
title_sort μ‐opioid receptor gene a118g polymorphism is associated with insecure attachment in children with disruptive mood regulation disorder and their mothers
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375094/
https://www.ncbi.nlm.nih.gov/pubmed/32424914
http://dx.doi.org/10.1002/brb3.1659
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