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Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study

BACKGROUND: Obsessive–compulsive disorder (OCD) is a complex disorder with 40%–60% of patients' refractory to treatment. Transcranial direct current stimulation (tDCS) has been shown to induce potent and long‐lasting effects on cortical excitability. The aim of the present clinical trial was to...

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Autores principales: Harika‐Germaneau, Ghina, Heit, Damien, Chatard, Armand, Thirioux, Berangere, Langbour, Nicolas, Jaafari, Nemat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375126/
https://www.ncbi.nlm.nih.gov/pubmed/32406608
http://dx.doi.org/10.1002/brb3.1648
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author Harika‐Germaneau, Ghina
Heit, Damien
Chatard, Armand
Thirioux, Berangere
Langbour, Nicolas
Jaafari, Nemat
author_facet Harika‐Germaneau, Ghina
Heit, Damien
Chatard, Armand
Thirioux, Berangere
Langbour, Nicolas
Jaafari, Nemat
author_sort Harika‐Germaneau, Ghina
collection PubMed
description BACKGROUND: Obsessive–compulsive disorder (OCD) is a complex disorder with 40%–60% of patients' refractory to treatment. Transcranial direct current stimulation (tDCS) has been shown to induce potent and long‐lasting effects on cortical excitability. The aim of the present clinical trial was to evaluate the therapeutic efficacy and tolerability of cathodal tDCS over the supplementary motor area (SMA) in treatment‐resistant OCD patients. METHODS: Twenty‐one treatment‐resistant OCD outpatients received 10 sessions of tDCS. Each treatment session consisted of 2 mA stimuli for 30 min. The cathode was positioned over the bilateral SMA and the anode over the right supraorbital area. Patients were evaluated at baseline, end of treatment, one‐month follow‐up, and three‐month follow‐up. Response to treatment was defined as at least a decrease of 35% on the Yale–Brown Obsessive–Compulsive Scale (YBOCS) and a score of 2 or less on the Clinical Global Impressions‐Improvement (CGI‐I) between baseline and 1‐month follow‐up. RESULTS: There was a significant decrease of YBOCS scores between baseline and one‐month assessment. At one month, five patients (24%) were considered as responders and 3 (15%) at 3 months. We also observed concomitant changes in depressive symptoms, and insight. The treatment was well tolerated. Short‐lasting side effects were reported as localized tingling sensation and skin redness. CONCLUSION: Our results suggest that the use of cathodal tDCS over the SMA and anodal tDCS over the right supraorbital area in OCD treatment‐refractory patients is safe and promising to improve obsessive and compulsive symptoms. Large randomized controlled trials are needed to confirm this positive result.
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spelling pubmed-73751262020-07-22 Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study Harika‐Germaneau, Ghina Heit, Damien Chatard, Armand Thirioux, Berangere Langbour, Nicolas Jaafari, Nemat Brain Behav Original Research BACKGROUND: Obsessive–compulsive disorder (OCD) is a complex disorder with 40%–60% of patients' refractory to treatment. Transcranial direct current stimulation (tDCS) has been shown to induce potent and long‐lasting effects on cortical excitability. The aim of the present clinical trial was to evaluate the therapeutic efficacy and tolerability of cathodal tDCS over the supplementary motor area (SMA) in treatment‐resistant OCD patients. METHODS: Twenty‐one treatment‐resistant OCD outpatients received 10 sessions of tDCS. Each treatment session consisted of 2 mA stimuli for 30 min. The cathode was positioned over the bilateral SMA and the anode over the right supraorbital area. Patients were evaluated at baseline, end of treatment, one‐month follow‐up, and three‐month follow‐up. Response to treatment was defined as at least a decrease of 35% on the Yale–Brown Obsessive–Compulsive Scale (YBOCS) and a score of 2 or less on the Clinical Global Impressions‐Improvement (CGI‐I) between baseline and 1‐month follow‐up. RESULTS: There was a significant decrease of YBOCS scores between baseline and one‐month assessment. At one month, five patients (24%) were considered as responders and 3 (15%) at 3 months. We also observed concomitant changes in depressive symptoms, and insight. The treatment was well tolerated. Short‐lasting side effects were reported as localized tingling sensation and skin redness. CONCLUSION: Our results suggest that the use of cathodal tDCS over the SMA and anodal tDCS over the right supraorbital area in OCD treatment‐refractory patients is safe and promising to improve obsessive and compulsive symptoms. Large randomized controlled trials are needed to confirm this positive result. John Wiley and Sons Inc. 2020-05-14 /pmc/articles/PMC7375126/ /pubmed/32406608 http://dx.doi.org/10.1002/brb3.1648 Text en © 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Harika‐Germaneau, Ghina
Heit, Damien
Chatard, Armand
Thirioux, Berangere
Langbour, Nicolas
Jaafari, Nemat
Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study
title Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study
title_full Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study
title_fullStr Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study
title_full_unstemmed Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study
title_short Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study
title_sort treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: an open label study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375126/
https://www.ncbi.nlm.nih.gov/pubmed/32406608
http://dx.doi.org/10.1002/brb3.1648
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