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Clinical relevance of serum omentin‐1 levels as a biomarker of prognosis in patients with acute cerebral infarction

BACKGROUND AND PURPOSE: Previous studies have shown that adipocytokines are associated with atherosclerosis, diagnosis, and functional prognosis after ischemic stroke. However, few studies have investigated the relationship between omentin‐1 and atherosclerotic acute cerebral infarction (ACI). METHO...

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Autores principales: Yang, Jingyi, Gao, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375127/
https://www.ncbi.nlm.nih.gov/pubmed/32478488
http://dx.doi.org/10.1002/brb3.1678
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author Yang, Jingyi
Gao, Yan
author_facet Yang, Jingyi
Gao, Yan
author_sort Yang, Jingyi
collection PubMed
description BACKGROUND AND PURPOSE: Previous studies have shown that adipocytokines are associated with atherosclerosis, diagnosis, and functional prognosis after ischemic stroke. However, few studies have investigated the relationship between omentin‐1 and atherosclerotic acute cerebral infarction (ACI). METHODS: In this study, we investigated the association between serum omentin‐1 levels at admission and severity, infarction volume, and functional prognosis of patients 90 days after atherosclerotic ACI. RESULTS: A total of 109 patients with atherosclerotic ACI were enrolled. Serum omentin‐1 levels at admission were lower in patients with ACI than those in healthy controls (47.18 ± 13.64 vs. 56.27 ± 34.44 ng/ml, p = .014). Serum omentin‐1 levels at admission were negatively correlated with severity of ACI (r = −.271, p = .004) and infarction volume (r = −.264, p = .006), respectively. Moreover, serum omentin‐1 levels were lower in the poor functional prognosis group than those in the good functional prognosis group in patients with large artery and small artery atherosclerotic ACI. In a logistic regression analysis, higher serum omentin‐1 level (>43.10 ng/ml) at admission was negatively associated with a poor functional prognosis 90 days after atherosclerotic ACI. CONCLUSIONS: Serum omentin‐1 levels at admission were significantly lower among patients with ACI. A higher plasma omentin‐1 level (>43.10 ng/ml) was negatively associated with poor functional prognosis 90 days after atherosclerotic ACI. Further studies are needed to investigate the pathophysiological mechanism of omentin‐1 in affecting attacks and prognosis of ACI as well as to confirm the value of plasma omentin‐1 level as a potential biomarker.
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spelling pubmed-73751272020-07-22 Clinical relevance of serum omentin‐1 levels as a biomarker of prognosis in patients with acute cerebral infarction Yang, Jingyi Gao, Yan Brain Behav Original Research BACKGROUND AND PURPOSE: Previous studies have shown that adipocytokines are associated with atherosclerosis, diagnosis, and functional prognosis after ischemic stroke. However, few studies have investigated the relationship between omentin‐1 and atherosclerotic acute cerebral infarction (ACI). METHODS: In this study, we investigated the association between serum omentin‐1 levels at admission and severity, infarction volume, and functional prognosis of patients 90 days after atherosclerotic ACI. RESULTS: A total of 109 patients with atherosclerotic ACI were enrolled. Serum omentin‐1 levels at admission were lower in patients with ACI than those in healthy controls (47.18 ± 13.64 vs. 56.27 ± 34.44 ng/ml, p = .014). Serum omentin‐1 levels at admission were negatively correlated with severity of ACI (r = −.271, p = .004) and infarction volume (r = −.264, p = .006), respectively. Moreover, serum omentin‐1 levels were lower in the poor functional prognosis group than those in the good functional prognosis group in patients with large artery and small artery atherosclerotic ACI. In a logistic regression analysis, higher serum omentin‐1 level (>43.10 ng/ml) at admission was negatively associated with a poor functional prognosis 90 days after atherosclerotic ACI. CONCLUSIONS: Serum omentin‐1 levels at admission were significantly lower among patients with ACI. A higher plasma omentin‐1 level (>43.10 ng/ml) was negatively associated with poor functional prognosis 90 days after atherosclerotic ACI. Further studies are needed to investigate the pathophysiological mechanism of omentin‐1 in affecting attacks and prognosis of ACI as well as to confirm the value of plasma omentin‐1 level as a potential biomarker. John Wiley and Sons Inc. 2020-06-01 /pmc/articles/PMC7375127/ /pubmed/32478488 http://dx.doi.org/10.1002/brb3.1678 Text en © 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Yang, Jingyi
Gao, Yan
Clinical relevance of serum omentin‐1 levels as a biomarker of prognosis in patients with acute cerebral infarction
title Clinical relevance of serum omentin‐1 levels as a biomarker of prognosis in patients with acute cerebral infarction
title_full Clinical relevance of serum omentin‐1 levels as a biomarker of prognosis in patients with acute cerebral infarction
title_fullStr Clinical relevance of serum omentin‐1 levels as a biomarker of prognosis in patients with acute cerebral infarction
title_full_unstemmed Clinical relevance of serum omentin‐1 levels as a biomarker of prognosis in patients with acute cerebral infarction
title_short Clinical relevance of serum omentin‐1 levels as a biomarker of prognosis in patients with acute cerebral infarction
title_sort clinical relevance of serum omentin‐1 levels as a biomarker of prognosis in patients with acute cerebral infarction
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375127/
https://www.ncbi.nlm.nih.gov/pubmed/32478488
http://dx.doi.org/10.1002/brb3.1678
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