Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion

The Rho family GTPases are crucial drivers of tumor growth and metastasis. However, it is difficult to develop GTPases inhibitors due to a lack of well‐characterized binding pockets for compounds. Here, through molecular dynamics simulation of the RhoA protein, a groove around cysteine 107 (Cys107)...

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Detalles Bibliográficos
Autores principales: Sun, Zhongya, Zhang, Hao, Zhang, Yuanyuan, Liao, Liping, Zhou, Wen, Zhang, Fengcai, Lian, Fulin, Huang, Jing, Xu, Pan, Zhang, Rukang, Lu, Wenchao, Zhu, Mingrui, Tao, Hongru, Yang, Feng, Ding, Hong, Chen, Shijie, Yue, Liyan, Zhou, Bing, Zhang, Naixia, Tan, Minjia, Jiang, Hualiang, Chen, Kaixian, Liu, Bo, Liu, Chuanpeng, Dang, Yongjun, Luo, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375240/
https://www.ncbi.nlm.nih.gov/pubmed/32714746
http://dx.doi.org/10.1002/advs.202000098

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