Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation

RNA helicase DDX21 plays vital roles in ribosomal RNA biogenesis, transcription, and the regulation of host innate immunity during virus infection. How DDX21 recognizes and unwinds RNA and how DDX21 interacts with virus remain poorly understood. Here, crystal structures of human DDX21 determined in...

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Detalles Bibliográficos
Autores principales: Chen, Zijun, Li, Zhengyang, Hu, Xiaojian, Xie, Feiyan, Kuang, Siyun, Zhan, Bowen, Gao, Wenqing, Chen, Xiangjun, Gao, Siqi, Li, Yang, Wang, Yongming, Qian, Feng, Ding, Chen, Gan, Jianhua, Ji, Chaoneng, Xu, Xue‐Wei, Zhou, Zheng, Huang, Jinqing, He, Housheng Hansen, Li, Jixi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375243/
https://www.ncbi.nlm.nih.gov/pubmed/32714761
http://dx.doi.org/10.1002/advs.202000532

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