Cargando…

Cytotoxic and anticancer properties of the Malaysian mangrove pit viper (Trimeresurus purpureomaculatus) venom and its disintegrin (purpureomaculin)

BACKGROUND: The Asiatic pit vipers from the Trimeresurus complex are medically important venomous snakes. These pit vipers are often associated with snakebite that leads to fatal coagulopathy and tissue necrosis. The cytotoxic venoms of Trimeresurus spp.; however, hold great potential for the develo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, Choo Hock, Liew, Jia Lee, Navanesan, Suerialoasan, Sim, Kae Shin, Tan, Nget Hong, Tan, Kae Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Centro de Estudos de Venenos e Animais Peçonhentos 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375409/ https://www.ncbi.nlm.nih.gov/pubmed/32742279 http://dx.doi.org/10.1590/1678-9199-JVATITD-2020-0013

Ejemplares similares

Venomics of Trimeresurus (Popeia) nebularis, the Cameron Highlands Pit Viper from Malaysia: Insights into Venom Proteome, Toxicity and Neutralization of Antivenom
por: Tan, Choo Hock, et al.
Publicado: (2019)

De Novo Assembly of Venom Gland Transcriptome of Tropidolaemus wagleri (Temple Pit Viper, Malaysia) and Insights into the Origin of Its Major Toxin, Waglerin
por: Tan, Choo Hock, et al.
Publicado: (2023)

Venomics of Tropidolaemus wagleri, the sexually dimorphic temple pit viper: Unveiling a deeply conserved atypical toxin arsenal
por: Tan, Choo Hock, et al.
Publicado: (2017)

Venom proteomics and antivenom neutralization for the Chinese eastern Russell’s viper, Daboia siamensis from Guangxi and Taiwan
por: Tan, Kae Yi, et al.
Publicado: (2018)

Venom composition of Trimeresurus albolabris, T. insularis, T. puniceus and T. purpureomaculatus from Indonesia
por: Anita, Syahfitri, et al.
Publicado: (2022)

Venom-gland transcriptome and venom proteome of the Malaysian king cobra (Ophiophagus hannah)
por: Tan, Choo Hock, et al.
Publicado: (2015)

Venomics and Cellular Toxicity of Thai Pit Vipers (Trimeresurus macrops and T. hageni)
por: Kumkate, Supeecha, et al.
Publicado: (2020)

De Novo Venom Gland Transcriptome Assembly and Characterization for Calloselasma rhodostoma (Kuhl, 1824), the Malayan Pit Viper from Malaysia: Unravelling Toxin Gene Diversity in a Medically Important Basal Crotaline
por: Tan, Choo Hock, et al.
Publicado: (2023)

Snake Venom Proteomics, Immunoreactivity and Toxicity Neutralization Studies for the Asiatic Mountain Pit Vipers, Ovophis convictus, Ovophis tonkinensis, and Hime Habu, Ovophis okinavensis
por: Tan, Choo Hock, et al.
Publicado: (2021)

Proteomics, toxicity and antivenom neutralization of Sri Lankan and Indian Russell’s viper (Daboia russelii) venoms
por: Faisal, Tasnim, et al.
Publicado: (2021)

Antivenom Cross-Neutralization of the Venoms of Hydrophis schistosus and Hydrophis curtus, Two Common Sea Snakes in Malaysian Waters
por: Tan, Choo Hock, et al.
Publicado: (2015)

Neutralization of the Principal Toxins from the Venoms of Thai Naja kaouthia and Malaysian Hydrophis schistosus: Insights into Toxin-Specific Neutralization by Two Different Antivenoms
por: Tan, Kae Yi, et al.
Publicado: (2016)

Proteomics and antivenom immunoprofiling of Russell’s viper (Daboia siamensis) venoms from Thailand and Indonesia
por: Lingam, Thava Malar Changra, et al.
Publicado: (2020)

Comparative venom gland transcriptomics of Naja kaouthia (monocled cobra) from Malaysia and Thailand: elucidating geographical venom variation and insights into sequence novelty
por: Tan, Kae Yi, et al.
Publicado: (2017)

A Neurotoxic Snake Venom without Phospholipase A(2): Proteomics and Cross-Neutralization of the Venom from Senegalese Cobra, Naja senegalensis (Subgenus: Uraeus)
por: Wong, Kin Ying, et al.
Publicado: (2021)

Assessing SABU (Serum Anti Bisa Ular), the sole Indonesian antivenom: A proteomic analysis and neutralization efficacy study
por: Tan, Choo Hock, et al.
Publicado: (2016)

Elucidating the Venom Diversity in Sri Lankan Spectacled Cobra (Naja naja) through De Novo Venom Gland Transcriptomics, Venom Proteomics and Toxicity Neutralization
por: Wong, Kin Ying, et al.
Publicado: (2021)

Exploring the Diversity and Novelty of Toxin Genes in Naja sumatrana, the Equatorial Spitting Cobra from Malaysia through De Novo Venom-Gland Transcriptomics
por: Chong, Ho Phin, et al.
Publicado: (2019)

Proteomic Characterization and Comparison of Malaysian Tropidolaemus wagleri and Cryptelytrops purpureomaculatus Venom Using Shotgun-Proteomics
por: Zainal Abidin, Syafiq Asnawi, et al.
Publicado: (2016)

Distinctive Distribution of Secretory Phospholipases A(2) in the Venoms of Afro-Asian Cobras (Subgenus: Naja, Afronaja, Boulengerina and Uraeus)
por: Tan, Choo Hock, et al.
Publicado: (2019)

Evaluation of selected biological capacities of Baeckea frutescens
por: Navanesan, Suerialoasan, et al.
Publicado: (2015)

Leptospermum flavescens Constituent-LF1 Causes Cell Death through the Induction of Cell Cycle Arrest and Apoptosis in Human Lung Carcinoma Cells
por: Navanesan, Suerialoasan, et al.
Publicado: (2015)

Venom Proteome of Spine-Bellied Sea Snake (Hydrophis curtus) from Penang, Malaysia: Toxicity Correlation, Immunoprofiling and Cross-Neutralization by Sea Snake Antivenom
por: Tan, Choo Hock, et al.
Publicado: (2018)

Snake Venomics and Antivenomics of Cape Cobra (Naja nivea) from South Africa: Insights into Venom Toxicity and Cross-Neutralization Activity
por: Tan, Choo Hock, et al.
Publicado: (2022)

Equatorial Spitting Cobra (Naja sumatrana) from Malaysia (Negeri Sembilan and Penang), Southern Thailand, and Sumatra: Comparative Venom Proteomics, Immunoreactivity and Cross-Neutralization by Antivenom
por: Tan, Choo Hock, et al.
Publicado: (2022)

A new cryptic species of green pit viper of the genus Trimeresurus Lacépède, 1804 (Serpentes, Viperidae) from northeast India
por: Rathee, Yashpal Singh, et al.
Publicado: (2022)

Thrombolytic Effects of Philippine Pit Viper (Trimeresurus flavomaculatus) Venom in Human Blood In Vitro and Ferric Chloride-Induced Cardiac Thrombosis on Swiss Webster Mice In Vivo
por: Alcachupas, Aljeirou, et al.
Publicado: (2023)

De Novo Venom-Gland Transcriptomics of Spine-Bellied Sea Snake (Hydrophis curtus) from Penang, Malaysia—Next-Generation Sequencing, Functional Annotation and Toxinological Correlation
por: Tan, Choo Hock, et al.
Publicado: (2021)

Phenolic content, antioxidant effect and cytotoxic activity of Leea indica leaves
por: Reddy, Nidyaletchmy Subba, et al.
Publicado: (2012)

De novo venom gland transcriptomics of Calliophis bivirgata flaviceps: uncovering the complexity of toxins from the Malayan blue coral snake
por: Palasuberniam, Praneetha, et al.
Publicado: (2021)

Editorial: Venoms and Toxins: Functional Omics and Pharmacological Insights
por: Tan, Choo Hock, et al.
Publicado: (2022)

Proteomic Analysis, Immuno-Specificity and Neutralization Efficacy of Pakistani Viper Antivenom (PVAV), a Bivalent Anti-Viperid Antivenom Produced in Pakistan
por: Lim, Andy Shing Seng, et al.
Publicado: (2023)

Cytotoxicity of Snake Venoms and Cytotoxins From Two Southeast Asian Cobras (Naja sumatrana, Naja kaouthia): Exploration of Anticancer Potential, Selectivity, and Cell Death Mechanism
por: Chong, Ho Phin, et al.
Publicado: (2020)

An immunoinformatic approach to assessing the immunogenic capacity of alpha-neurotoxins in elapid snake venoms
por: Chan, Yi Wei, et al.
Publicado: (2023)

Snake Venom Proteomics of Samar Cobra (Naja samarensis) from the Southern Philippines: Short Alpha-Neurotoxins as the Dominant Lethal Component Weakly Cross-Neutralized by the Philippine Cobra Antivenom
por: Palasuberniam, Praneetha, et al.
Publicado: (2021)

Proteomic Characterization of Two Medically Important Malaysian Snake Venoms, Calloselasma rhodostoma (Malayan Pit Viper) and Ophiophagus hannah (King Cobra)
por: Kunalan, Sugita, et al.
Publicado: (2018)

Cytotoxic, Anti-Proliferative and Apoptosis Activity of l-Amino Acid Oxidase from Malaysian Cryptelytrops purpureomaculatus (CP-LAAO) Venom on Human Colon Cancer Cells
por: Zainal Abidin, Syafiq Asnawi, et al.
Publicado: (2018)

A Simple and Novel Strategy for the Production of a Pan-specific Antiserum against Elapid Snakes of Asia
por: Ratanabanangkoon, Kavi, et al.
Publicado: (2016)

Proteomics and immunocharacterization of Asian mountain pit viper (Ovophis monticola) venom
por: Sitprija, Siravit, et al.
Publicado: (2021)

King Cobra and snakebite envenomation: on the natural history, human-snake relationship and medical importance of Ophiophagus hannah
por: Tan, Choo Hock, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nr3jktuf2s59o0v42s8ak5jghk