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Association between brachial-ankle pulse wave velocity and risk of type 2 diabetes mellitus: results from a cohort study
INTRODUCTION: Brachial-ankle pulse wave velocity (ba-PWV), as a simple and easily measured marker of arterial stiffness, has not been prospectively explored for its role in type 2 diabetes mellitus (T2DM) risk among the general population. This study aimed to explore the association between baseline...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375424/ https://www.ncbi.nlm.nih.gov/pubmed/32699113 http://dx.doi.org/10.1136/bmjdrc-2020-001317 |
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author | Lou, Yan-mei Liao, Min-qi Wang, Chang-yi Chen, Hong-en Peng, Xiao-lin Zhao, Dan Gao, Xu-ping Xu, Shan Wang, Li Ma, Jian-ping Ping, Zhao Zeng, Fang-fang |
author_facet | Lou, Yan-mei Liao, Min-qi Wang, Chang-yi Chen, Hong-en Peng, Xiao-lin Zhao, Dan Gao, Xu-ping Xu, Shan Wang, Li Ma, Jian-ping Ping, Zhao Zeng, Fang-fang |
author_sort | Lou, Yan-mei |
collection | PubMed |
description | INTRODUCTION: Brachial-ankle pulse wave velocity (ba-PWV), as a simple and easily measured marker of arterial stiffness, has not been prospectively explored for its role in type 2 diabetes mellitus (T2DM) risk among the general population. This study aimed to explore the association between baseline ba-PWV value and new-onset T2DM among Chinese adults. RESEARCH DESIGN AND METHODS: Using data from Xiaotangshan Hospital, we conducted a prospective cohort study among those who underwent annual or biennial health check-up examinations and who had their ba-PWV measured from 2009 to 2016. We explored the risk of new-onset T2DM across ba-PWV tertiles using Cox proportional-hazards regression analysis. RESULTS: Of 6122 adults (68.9% male; mean age: 51.0 (SD 13.0) years) without T2DM and with ba-PWV measured at baseline, 599 participants developed T2DM during an average of 3.8 (SD 2.3) years of follow-up. After multivariable adjustment, ba-PWV was positively related to T2DM risk (p for trend=0.008). Compared with the lowest ba-PWV tertile, the HRs and their 95% CIs were 1.57 (1.18 to 2.10) for the second and 1.66 (1.24 to 2.22) for the third tertile. The risk across ba-PWV tertiles increased steadily from 1000 cm/s to 1400 cm/s and then reached a plateau. Subgroup analyses indicated a significantly higher risk among those aged <65 years and current smokers (p for interactions: <0.001 and 0.006). CONCLUSIONS: Our findings suggest that ba-PWV might be a useful and independent predictor of new-onset T2DM with ba-PWV ranging between 1000 cm/s and 1400 cm/s, especially among younger individuals and current smokers. |
format | Online Article Text |
id | pubmed-7375424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-73754242020-07-27 Association between brachial-ankle pulse wave velocity and risk of type 2 diabetes mellitus: results from a cohort study Lou, Yan-mei Liao, Min-qi Wang, Chang-yi Chen, Hong-en Peng, Xiao-lin Zhao, Dan Gao, Xu-ping Xu, Shan Wang, Li Ma, Jian-ping Ping, Zhao Zeng, Fang-fang BMJ Open Diabetes Res Care Cardiovascular and Metabolic Risk INTRODUCTION: Brachial-ankle pulse wave velocity (ba-PWV), as a simple and easily measured marker of arterial stiffness, has not been prospectively explored for its role in type 2 diabetes mellitus (T2DM) risk among the general population. This study aimed to explore the association between baseline ba-PWV value and new-onset T2DM among Chinese adults. RESEARCH DESIGN AND METHODS: Using data from Xiaotangshan Hospital, we conducted a prospective cohort study among those who underwent annual or biennial health check-up examinations and who had their ba-PWV measured from 2009 to 2016. We explored the risk of new-onset T2DM across ba-PWV tertiles using Cox proportional-hazards regression analysis. RESULTS: Of 6122 adults (68.9% male; mean age: 51.0 (SD 13.0) years) without T2DM and with ba-PWV measured at baseline, 599 participants developed T2DM during an average of 3.8 (SD 2.3) years of follow-up. After multivariable adjustment, ba-PWV was positively related to T2DM risk (p for trend=0.008). Compared with the lowest ba-PWV tertile, the HRs and their 95% CIs were 1.57 (1.18 to 2.10) for the second and 1.66 (1.24 to 2.22) for the third tertile. The risk across ba-PWV tertiles increased steadily from 1000 cm/s to 1400 cm/s and then reached a plateau. Subgroup analyses indicated a significantly higher risk among those aged <65 years and current smokers (p for interactions: <0.001 and 0.006). CONCLUSIONS: Our findings suggest that ba-PWV might be a useful and independent predictor of new-onset T2DM with ba-PWV ranging between 1000 cm/s and 1400 cm/s, especially among younger individuals and current smokers. BMJ Publishing Group 2020-07-21 /pmc/articles/PMC7375424/ /pubmed/32699113 http://dx.doi.org/10.1136/bmjdrc-2020-001317 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Cardiovascular and Metabolic Risk Lou, Yan-mei Liao, Min-qi Wang, Chang-yi Chen, Hong-en Peng, Xiao-lin Zhao, Dan Gao, Xu-ping Xu, Shan Wang, Li Ma, Jian-ping Ping, Zhao Zeng, Fang-fang Association between brachial-ankle pulse wave velocity and risk of type 2 diabetes mellitus: results from a cohort study |
title | Association between brachial-ankle pulse wave velocity and risk of type 2 diabetes mellitus: results from a cohort study |
title_full | Association between brachial-ankle pulse wave velocity and risk of type 2 diabetes mellitus: results from a cohort study |
title_fullStr | Association between brachial-ankle pulse wave velocity and risk of type 2 diabetes mellitus: results from a cohort study |
title_full_unstemmed | Association between brachial-ankle pulse wave velocity and risk of type 2 diabetes mellitus: results from a cohort study |
title_short | Association between brachial-ankle pulse wave velocity and risk of type 2 diabetes mellitus: results from a cohort study |
title_sort | association between brachial-ankle pulse wave velocity and risk of type 2 diabetes mellitus: results from a cohort study |
topic | Cardiovascular and Metabolic Risk |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375424/ https://www.ncbi.nlm.nih.gov/pubmed/32699113 http://dx.doi.org/10.1136/bmjdrc-2020-001317 |
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