An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses

CD137 is a costimulatory receptor expressed on natural killer cells, T cells, and subsets of dendritic cells. An agonistic monoclonal antibody (mAb) against CD137 has been used to reduce tumor burden or reverse autoimmunity in animal models and clinical trials. Here, we show that mice treated with a...

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Detalles Bibliográficos
Autores principales: Hong, Jun P., Reynoso, Glennys V., Andhey, Prabhakar S., Swain, Amanda, Turner, Jackson S., Boon, Adrianus C.M., Krammer, Florian, Ellebedy, Ali H., Zanini, Fabio, Artyomov, Maxim, Hickman, Heather D., Diamond, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375459/
https://www.ncbi.nlm.nih.gov/pubmed/32699843
http://dx.doi.org/10.1016/j.xcrm.2020.100035

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