Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis()

PURPOSE: We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of...

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Autores principales: Ben-David, Merav A., Corn, Benjamin W., Evron, Ella, Goldberg, Hadassah, Pfeffer, Raphael M., Abdah-Bortnyak, Roxoliana, Matceyevsky, Dianna, Weinstein, Yuliana, Golan, Orit, Sklair-Levy, Miri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375590/
https://www.ncbi.nlm.nih.gov/pubmed/31734591
http://dx.doi.org/10.1016/j.breast.2019.10.011
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author Ben-David, Merav A.
Corn, Benjamin W.
Evron, Ella
Goldberg, Hadassah
Pfeffer, Raphael M.
Abdah-Bortnyak, Roxoliana
Matceyevsky, Dianna
Weinstein, Yuliana
Golan, Orit
Sklair-Levy, Miri
author_facet Ben-David, Merav A.
Corn, Benjamin W.
Evron, Ella
Goldberg, Hadassah
Pfeffer, Raphael M.
Abdah-Bortnyak, Roxoliana
Matceyevsky, Dianna
Weinstein, Yuliana
Golan, Orit
Sklair-Levy, Miri
author_sort Ben-David, Merav A.
collection PubMed
description PURPOSE: We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer. METHODS: For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density. RESULTS: Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group. CONCLUSION: Reduction of BPE by PBI may contribute to its prophylactic effect.
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spelling pubmed-73755902020-07-29 Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis() Ben-David, Merav A. Corn, Benjamin W. Evron, Ella Goldberg, Hadassah Pfeffer, Raphael M. Abdah-Bortnyak, Roxoliana Matceyevsky, Dianna Weinstein, Yuliana Golan, Orit Sklair-Levy, Miri Breast Short Communication PURPOSE: We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer. METHODS: For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density. RESULTS: Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group. CONCLUSION: Reduction of BPE by PBI may contribute to its prophylactic effect. Elsevier 2019-11-06 /pmc/articles/PMC7375590/ /pubmed/31734591 http://dx.doi.org/10.1016/j.breast.2019.10.011 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Ben-David, Merav A.
Corn, Benjamin W.
Evron, Ella
Goldberg, Hadassah
Pfeffer, Raphael M.
Abdah-Bortnyak, Roxoliana
Matceyevsky, Dianna
Weinstein, Yuliana
Golan, Orit
Sklair-Levy, Miri
Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis()
title Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis()
title_full Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis()
title_fullStr Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis()
title_full_unstemmed Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis()
title_short Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis()
title_sort prophylactic breast irradiation reduces background parenchymal enhancement (bpe) on mri: a secondary analysis()
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375590/
https://www.ncbi.nlm.nih.gov/pubmed/31734591
http://dx.doi.org/10.1016/j.breast.2019.10.011
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