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Changes in weight, physical and psychosocial patient-reported outcomes among obese women receiving treatment for early-stage breast cancer: A nationwide clinical study

BACKGROUND: Evidence on how weight loss correlates to health-related quality-of-life (HRQOL) among obese breast cancer (BC) patients is limited. We aimed to evaluate associations between weight changes and HRQOL. METHODS: We included 993 obese women with stage I-II-III BC from CANTO, a multicenter,...

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Autores principales: Di Meglio, Antonio, Michiels, Stefan, Jones, Lee W., El-Mouhebb, Mayssam, Ferreira, Arlindo R., Martin, Elise, Matias, Margarida, Lohmann, Ana Elisa, Joly, Florence, Vanlemmens, Laurence, Everhard, Sibille, Martin, Anne-Laure, Lemonnier, Jerome, Arveux, Patrick, Cottu, Paul H., Coutant, Charles, Del Mastro, Lucia, Partridge, Ann H., André, Fabrice, Ligibel, Jennifer A., Vaz-Luis, Ines
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375600/
https://www.ncbi.nlm.nih.gov/pubmed/32344296
http://dx.doi.org/10.1016/j.breast.2020.04.002
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author Di Meglio, Antonio
Michiels, Stefan
Jones, Lee W.
El-Mouhebb, Mayssam
Ferreira, Arlindo R.
Martin, Elise
Matias, Margarida
Lohmann, Ana Elisa
Joly, Florence
Vanlemmens, Laurence
Everhard, Sibille
Martin, Anne-Laure
Lemonnier, Jerome
Arveux, Patrick
Cottu, Paul H.
Coutant, Charles
Del Mastro, Lucia
Partridge, Ann H.
André, Fabrice
Ligibel, Jennifer A.
Vaz-Luis, Ines
author_facet Di Meglio, Antonio
Michiels, Stefan
Jones, Lee W.
El-Mouhebb, Mayssam
Ferreira, Arlindo R.
Martin, Elise
Matias, Margarida
Lohmann, Ana Elisa
Joly, Florence
Vanlemmens, Laurence
Everhard, Sibille
Martin, Anne-Laure
Lemonnier, Jerome
Arveux, Patrick
Cottu, Paul H.
Coutant, Charles
Del Mastro, Lucia
Partridge, Ann H.
André, Fabrice
Ligibel, Jennifer A.
Vaz-Luis, Ines
author_sort Di Meglio, Antonio
collection PubMed
description BACKGROUND: Evidence on how weight loss correlates to health-related quality-of-life (HRQOL) among obese breast cancer (BC) patients is limited. We aimed to evaluate associations between weight changes and HRQOL. METHODS: We included 993 obese women with stage I-II-III BC from CANTO, a multicenter, prospective cohort collecting longitudinal, objectively-assessed anthropometric measures and HRQOL data (NCT01993498). Associations between weight changes (±5% between diagnosis and post-treatment [shortly after completion of surgery, adjuvant chemo- or radiation-therapy]) and patient-reported HRQOL (EORTC QLQ-C30/B23) were comprehensively evaluated. Changes in HRQOL and odds of severely impaired HRQOL were assessed using multivariable generalized estimating equations and logistic regression, respectively. RESULTS: 14.1% women gained weight, 67.3% remained stable and 18.6% lost weight. Significant decreases in functional status and exacerbation of symptoms were observed overall post-treatment. Compared to gaining weight or remaining stable, obese women who lost weight experienced less of a decline in HRQOL, reporting better physical function (mean change [95%CI] for gain, stability and loss: −12.9 [-16.5,-9.3], −6.9 [-8.2,-5.5] and −6.2 [-8.7,-3.7]; p(interaction[weight-change-by-time]) = 0.006), less dyspnea (+18.9 [+12.3,+25.6], +9.2 [+6.5,+11.9] and +3.2 [-1.0,+7.3]; p(interaction) = 0.0003), and fewer breast symptoms (+22.1 [+16.8,+27.3], +18.0 [+15.7,+20.3] and +13.4 [+9.0,+17.2]; p(interaction) = 0.044). Weight loss was also significantly associated with reduced odds of severe pain compared with weight gain (OR [95%CI] = 0.51 [0.31–0.86], p = 0.011) or stability (OR [95%CI] = 0.62 [0.41–0.95], p = 0.029). No associations between weight loss and worsening of other physical or psychosocial parameters were found. CONCLUSIONS: This large contemporary study suggests that weight loss among obese BC patients during early survivorship was associated with better patient-reported outcomes, without evidence of worsened functionality or symptomatology in any domain of HRQOL.
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spelling pubmed-73756002020-07-29 Changes in weight, physical and psychosocial patient-reported outcomes among obese women receiving treatment for early-stage breast cancer: A nationwide clinical study Di Meglio, Antonio Michiels, Stefan Jones, Lee W. El-Mouhebb, Mayssam Ferreira, Arlindo R. Martin, Elise Matias, Margarida Lohmann, Ana Elisa Joly, Florence Vanlemmens, Laurence Everhard, Sibille Martin, Anne-Laure Lemonnier, Jerome Arveux, Patrick Cottu, Paul H. Coutant, Charles Del Mastro, Lucia Partridge, Ann H. André, Fabrice Ligibel, Jennifer A. Vaz-Luis, Ines Breast Original Article BACKGROUND: Evidence on how weight loss correlates to health-related quality-of-life (HRQOL) among obese breast cancer (BC) patients is limited. We aimed to evaluate associations between weight changes and HRQOL. METHODS: We included 993 obese women with stage I-II-III BC from CANTO, a multicenter, prospective cohort collecting longitudinal, objectively-assessed anthropometric measures and HRQOL data (NCT01993498). Associations between weight changes (±5% between diagnosis and post-treatment [shortly after completion of surgery, adjuvant chemo- or radiation-therapy]) and patient-reported HRQOL (EORTC QLQ-C30/B23) were comprehensively evaluated. Changes in HRQOL and odds of severely impaired HRQOL were assessed using multivariable generalized estimating equations and logistic regression, respectively. RESULTS: 14.1% women gained weight, 67.3% remained stable and 18.6% lost weight. Significant decreases in functional status and exacerbation of symptoms were observed overall post-treatment. Compared to gaining weight or remaining stable, obese women who lost weight experienced less of a decline in HRQOL, reporting better physical function (mean change [95%CI] for gain, stability and loss: −12.9 [-16.5,-9.3], −6.9 [-8.2,-5.5] and −6.2 [-8.7,-3.7]; p(interaction[weight-change-by-time]) = 0.006), less dyspnea (+18.9 [+12.3,+25.6], +9.2 [+6.5,+11.9] and +3.2 [-1.0,+7.3]; p(interaction) = 0.0003), and fewer breast symptoms (+22.1 [+16.8,+27.3], +18.0 [+15.7,+20.3] and +13.4 [+9.0,+17.2]; p(interaction) = 0.044). Weight loss was also significantly associated with reduced odds of severe pain compared with weight gain (OR [95%CI] = 0.51 [0.31–0.86], p = 0.011) or stability (OR [95%CI] = 0.62 [0.41–0.95], p = 0.029). No associations between weight loss and worsening of other physical or psychosocial parameters were found. CONCLUSIONS: This large contemporary study suggests that weight loss among obese BC patients during early survivorship was associated with better patient-reported outcomes, without evidence of worsened functionality or symptomatology in any domain of HRQOL. Elsevier 2020-04-11 /pmc/articles/PMC7375600/ /pubmed/32344296 http://dx.doi.org/10.1016/j.breast.2020.04.002 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Di Meglio, Antonio
Michiels, Stefan
Jones, Lee W.
El-Mouhebb, Mayssam
Ferreira, Arlindo R.
Martin, Elise
Matias, Margarida
Lohmann, Ana Elisa
Joly, Florence
Vanlemmens, Laurence
Everhard, Sibille
Martin, Anne-Laure
Lemonnier, Jerome
Arveux, Patrick
Cottu, Paul H.
Coutant, Charles
Del Mastro, Lucia
Partridge, Ann H.
André, Fabrice
Ligibel, Jennifer A.
Vaz-Luis, Ines
Changes in weight, physical and psychosocial patient-reported outcomes among obese women receiving treatment for early-stage breast cancer: A nationwide clinical study
title Changes in weight, physical and psychosocial patient-reported outcomes among obese women receiving treatment for early-stage breast cancer: A nationwide clinical study
title_full Changes in weight, physical and psychosocial patient-reported outcomes among obese women receiving treatment for early-stage breast cancer: A nationwide clinical study
title_fullStr Changes in weight, physical and psychosocial patient-reported outcomes among obese women receiving treatment for early-stage breast cancer: A nationwide clinical study
title_full_unstemmed Changes in weight, physical and psychosocial patient-reported outcomes among obese women receiving treatment for early-stage breast cancer: A nationwide clinical study
title_short Changes in weight, physical and psychosocial patient-reported outcomes among obese women receiving treatment for early-stage breast cancer: A nationwide clinical study
title_sort changes in weight, physical and psychosocial patient-reported outcomes among obese women receiving treatment for early-stage breast cancer: a nationwide clinical study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375600/
https://www.ncbi.nlm.nih.gov/pubmed/32344296
http://dx.doi.org/10.1016/j.breast.2020.04.002
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