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Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI

PURPOSE: We conducted this study to investigate the prognosis and failure pattern after breast-conserving treatment (BCT) in patients with occult breast cancer (OBC) with negative breast magnetic resonance imaging (MRI) (MRI-OBC). MATERIALS AND METHODS: Survival rates and failure patterns in 66 pati...

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Autores principales: Kim, Haeyoung, Park, Won, Kim, Su Ssan, Ahn, Sung Ja, Kim, Yong Bae, Kim, Tae Hyun, Kim, Jin Hee, Choi, Jin-Hwa, Park, Hae Jin, Chang, Jee Suk, Choi, Doo Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375624/
https://www.ncbi.nlm.nih.gov/pubmed/31734590
http://dx.doi.org/10.1016/j.breast.2019.10.017
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author Kim, Haeyoung
Park, Won
Kim, Su Ssan
Ahn, Sung Ja
Kim, Yong Bae
Kim, Tae Hyun
Kim, Jin Hee
Choi, Jin-Hwa
Park, Hae Jin
Chang, Jee Suk
Choi, Doo Ho
author_facet Kim, Haeyoung
Park, Won
Kim, Su Ssan
Ahn, Sung Ja
Kim, Yong Bae
Kim, Tae Hyun
Kim, Jin Hee
Choi, Jin-Hwa
Park, Hae Jin
Chang, Jee Suk
Choi, Doo Ho
author_sort Kim, Haeyoung
collection PubMed
description PURPOSE: We conducted this study to investigate the prognosis and failure pattern after breast-conserving treatment (BCT) in patients with occult breast cancer (OBC) with negative breast magnetic resonance imaging (MRI) (MRI-OBC). MATERIALS AND METHODS: Survival rates and failure patterns in 66 patients who received axillary lymph node dissection (ALND) and BCT for MRI-OBC between 2001 and 2013 at seven hospitals were analyzed. OBC was defined as adenocarcinoma in the axillary lymph node (ALN) +/− supraclavicular (SCN) or internal mammary lymph node (IMN) with a negative breast MRI. RESULTS: Fifty-four patients had only ALN metastasis (ALN only), and 12 patients had ALN metastasis along with SCN or IMN metastasis (ALN + SCN/IMN). Median follow-up was 82 months. The 5-year overall, disease-free, and breast cancer-free survival rates were 93.4%, 92.1%, and 96.8%, respectively. Nine patients experienced recurrence: breast (n = 4), regional lymph nodes (RLN, n = 1), distant metastases (DM, n = 2), breast/RLN (n = 1), and breast/RLN/DM (n = 1). Five-year disease-free survival was significantly higher in ALN only patients compared to ALN + SCN/IMN patients (96.1% vs. 75.0%; p = 0.02). CONCLUSIONS: Patients with MRI-OBC were successfully treated with BCT. There was a small risk of ipsilateral breast cancer recurrence. Failure patterns depended on the extent of initial disease.
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spelling pubmed-73756242020-07-29 Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI Kim, Haeyoung Park, Won Kim, Su Ssan Ahn, Sung Ja Kim, Yong Bae Kim, Tae Hyun Kim, Jin Hee Choi, Jin-Hwa Park, Hae Jin Chang, Jee Suk Choi, Doo Ho Breast Original Article PURPOSE: We conducted this study to investigate the prognosis and failure pattern after breast-conserving treatment (BCT) in patients with occult breast cancer (OBC) with negative breast magnetic resonance imaging (MRI) (MRI-OBC). MATERIALS AND METHODS: Survival rates and failure patterns in 66 patients who received axillary lymph node dissection (ALND) and BCT for MRI-OBC between 2001 and 2013 at seven hospitals were analyzed. OBC was defined as adenocarcinoma in the axillary lymph node (ALN) +/− supraclavicular (SCN) or internal mammary lymph node (IMN) with a negative breast MRI. RESULTS: Fifty-four patients had only ALN metastasis (ALN only), and 12 patients had ALN metastasis along with SCN or IMN metastasis (ALN + SCN/IMN). Median follow-up was 82 months. The 5-year overall, disease-free, and breast cancer-free survival rates were 93.4%, 92.1%, and 96.8%, respectively. Nine patients experienced recurrence: breast (n = 4), regional lymph nodes (RLN, n = 1), distant metastases (DM, n = 2), breast/RLN (n = 1), and breast/RLN/DM (n = 1). Five-year disease-free survival was significantly higher in ALN only patients compared to ALN + SCN/IMN patients (96.1% vs. 75.0%; p = 0.02). CONCLUSIONS: Patients with MRI-OBC were successfully treated with BCT. There was a small risk of ipsilateral breast cancer recurrence. Failure patterns depended on the extent of initial disease. Elsevier 2019-11-06 /pmc/articles/PMC7375624/ /pubmed/31734590 http://dx.doi.org/10.1016/j.breast.2019.10.017 Text en © 2019 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Kim, Haeyoung
Park, Won
Kim, Su Ssan
Ahn, Sung Ja
Kim, Yong Bae
Kim, Tae Hyun
Kim, Jin Hee
Choi, Jin-Hwa
Park, Hae Jin
Chang, Jee Suk
Choi, Doo Ho
Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI
title Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI
title_full Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI
title_fullStr Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI
title_full_unstemmed Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI
title_short Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI
title_sort outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast mri
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375624/
https://www.ncbi.nlm.nih.gov/pubmed/31734590
http://dx.doi.org/10.1016/j.breast.2019.10.017
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