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CinéBreast-factors influencing the time to first metastatic recurrence in breast cancer: Analysis of real-life data from the French ESME MBC database

PURPOSE: The Time to First Metastatic Recurrence (TFMR) could be considered as an indirect reflection of the tumour growth kinetics which plays an important role in cancer. Molecular subtypes such as expression of estrogen receptor are known predictive factors of TFMR. The CinéBreast study aimed to...

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Autores principales: Gougis, P., Carton, M., Tchokothe, C., Campone, M., Dalenc, F., Mailliez, A., Levy, C., Jacot, W., Debled, M., Leheurteur, M., Bachelot, T., Hennequin, A., Perrin, C., Gonçalves, A., Uwer, L., Eymard, J.C., Petit, T., Mouret-Reynier, M.A., Chamorey, E., Simon, G., Saghatchian, M., Cailliot, C., Le Tourneau, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375625/
https://www.ncbi.nlm.nih.gov/pubmed/31675683
http://dx.doi.org/10.1016/j.breast.2019.10.004
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author Gougis, P.
Carton, M.
Tchokothe, C.
Campone, M.
Dalenc, F.
Mailliez, A.
Levy, C.
Jacot, W.
Debled, M.
Leheurteur, M.
Bachelot, T.
Hennequin, A.
Perrin, C.
Gonçalves, A.
Uwer, L.
Eymard, J.C.
Petit, T.
Mouret-Reynier, M.A.
Chamorey, E.
Simon, G.
Saghatchian, M.
Cailliot, C.
Le Tourneau, C.
author_facet Gougis, P.
Carton, M.
Tchokothe, C.
Campone, M.
Dalenc, F.
Mailliez, A.
Levy, C.
Jacot, W.
Debled, M.
Leheurteur, M.
Bachelot, T.
Hennequin, A.
Perrin, C.
Gonçalves, A.
Uwer, L.
Eymard, J.C.
Petit, T.
Mouret-Reynier, M.A.
Chamorey, E.
Simon, G.
Saghatchian, M.
Cailliot, C.
Le Tourneau, C.
author_sort Gougis, P.
collection PubMed
description PURPOSE: The Time to First Metastatic Recurrence (TFMR) could be considered as an indirect reflection of the tumour growth kinetics which plays an important role in cancer. Molecular subtypes such as expression of estrogen receptor are known predictive factors of TFMR. The CinéBreast study aimed to identify predictive factors of the time to TFMR. METHODS: The French Epidemiological Strategy and Medical Economics (ESME) Metastatic Breast Cancer (MBC) Database (NCT03275311) was used, which contains data from a cohort of metastatic breast cancer patients from 2008 to 2016 using retrospective data collection. It is a national multi-centre database. The impact of TFMR on overall survival (OS) since first metastasis was also evaluated. RESULTS: Among 16 702 patients recorded in the ESME MBC database, 10 595 had an initially localised breast cancer with hormone receptor (HR) and HER2 status available, with a metastatic recurrence. Median follow up was 56 months. Median TFMR was 59 months (<24: 20%, 24–60: 31%, 60–120: 25%, >120: 24%). HER2+ and TNBC were respectively 4 times and 12 times (p < 0.0001) more likely to have a recurrence within 2 years when compared to the luminal subgroup. Short TFMR and HR-/HER2-subtype significantly correlated with a poor OS in multivariate analysis. Some patients with MBC (20% in HER2+, 10% in ER+/HER2-and <5% in the ER-/HER2-) were long-term survivors in all 3 subgroups. CONCLUSIONS: In this large-scale real-life data study, patients with a TNBC metastatic recurrence had a shorter TFMR. Short TFMR significantly correlated with worse overall survival.
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spelling pubmed-73756252020-07-29 CinéBreast-factors influencing the time to first metastatic recurrence in breast cancer: Analysis of real-life data from the French ESME MBC database Gougis, P. Carton, M. Tchokothe, C. Campone, M. Dalenc, F. Mailliez, A. Levy, C. Jacot, W. Debled, M. Leheurteur, M. Bachelot, T. Hennequin, A. Perrin, C. Gonçalves, A. Uwer, L. Eymard, J.C. Petit, T. Mouret-Reynier, M.A. Chamorey, E. Simon, G. Saghatchian, M. Cailliot, C. Le Tourneau, C. Breast Original Article PURPOSE: The Time to First Metastatic Recurrence (TFMR) could be considered as an indirect reflection of the tumour growth kinetics which plays an important role in cancer. Molecular subtypes such as expression of estrogen receptor are known predictive factors of TFMR. The CinéBreast study aimed to identify predictive factors of the time to TFMR. METHODS: The French Epidemiological Strategy and Medical Economics (ESME) Metastatic Breast Cancer (MBC) Database (NCT03275311) was used, which contains data from a cohort of metastatic breast cancer patients from 2008 to 2016 using retrospective data collection. It is a national multi-centre database. The impact of TFMR on overall survival (OS) since first metastasis was also evaluated. RESULTS: Among 16 702 patients recorded in the ESME MBC database, 10 595 had an initially localised breast cancer with hormone receptor (HR) and HER2 status available, with a metastatic recurrence. Median follow up was 56 months. Median TFMR was 59 months (<24: 20%, 24–60: 31%, 60–120: 25%, >120: 24%). HER2+ and TNBC were respectively 4 times and 12 times (p < 0.0001) more likely to have a recurrence within 2 years when compared to the luminal subgroup. Short TFMR and HR-/HER2-subtype significantly correlated with a poor OS in multivariate analysis. Some patients with MBC (20% in HER2+, 10% in ER+/HER2-and <5% in the ER-/HER2-) were long-term survivors in all 3 subgroups. CONCLUSIONS: In this large-scale real-life data study, patients with a TNBC metastatic recurrence had a shorter TFMR. Short TFMR significantly correlated with worse overall survival. Elsevier 2019-10-19 /pmc/articles/PMC7375625/ /pubmed/31675683 http://dx.doi.org/10.1016/j.breast.2019.10.004 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Gougis, P.
Carton, M.
Tchokothe, C.
Campone, M.
Dalenc, F.
Mailliez, A.
Levy, C.
Jacot, W.
Debled, M.
Leheurteur, M.
Bachelot, T.
Hennequin, A.
Perrin, C.
Gonçalves, A.
Uwer, L.
Eymard, J.C.
Petit, T.
Mouret-Reynier, M.A.
Chamorey, E.
Simon, G.
Saghatchian, M.
Cailliot, C.
Le Tourneau, C.
CinéBreast-factors influencing the time to first metastatic recurrence in breast cancer: Analysis of real-life data from the French ESME MBC database
title CinéBreast-factors influencing the time to first metastatic recurrence in breast cancer: Analysis of real-life data from the French ESME MBC database
title_full CinéBreast-factors influencing the time to first metastatic recurrence in breast cancer: Analysis of real-life data from the French ESME MBC database
title_fullStr CinéBreast-factors influencing the time to first metastatic recurrence in breast cancer: Analysis of real-life data from the French ESME MBC database
title_full_unstemmed CinéBreast-factors influencing the time to first metastatic recurrence in breast cancer: Analysis of real-life data from the French ESME MBC database
title_short CinéBreast-factors influencing the time to first metastatic recurrence in breast cancer: Analysis of real-life data from the French ESME MBC database
title_sort cinébreast-factors influencing the time to first metastatic recurrence in breast cancer: analysis of real-life data from the french esme mbc database
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375625/
https://www.ncbi.nlm.nih.gov/pubmed/31675683
http://dx.doi.org/10.1016/j.breast.2019.10.004
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