Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse

Understanding T cell function in vivo is of key importance for basic and translational immunology alike. To study T cells in vivo, we developed a new knock-in mouse line, which expresses a fusion protein of granzyme B, a key component of cytotoxic granules involved in T cell-mediated target cell-kil...

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Detalles Bibliográficos
Autores principales: Chitirala, Praneeth, Chang, Hsin-Fang, Martzloff, Paloma, Harenberg, Christiane, Ravichandran, Keerthana, Abdulreda, Midhat H, Berggren, Per-Olof, Krause, Elmar, Schirra, Claudia, Leinders-Zufall, Trese, Benseler, Fritz, Brose, Nils, Rettig, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375811/
https://www.ncbi.nlm.nih.gov/pubmed/32696761
http://dx.doi.org/10.7554/eLife.58065

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