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Prevention of Hyperuricemia by Clerodendrum trichotomum Leaf Extract in Potassium Oxonate-Induced Mice

Clerodendrum trichotomum is a folk medicine exhibiting anti-hypertension, anti-arthritis, and anti-rheumatism properties. However, little is known about whether the material might prevent hyperuricemia and associated inflammation. In this study, we explored whether C. trichotomum leaf extract (CTE)...

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Autores principales: Jang, Mi Gyeong, Song, Hana, Kim, Ji Hye, Oh, Jung Min, Park, Jung Young, Ko, Hee Chul, Hur, Sung-Pyo, Kim, Se-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Developmental Biology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375980/
https://www.ncbi.nlm.nih.gov/pubmed/32734126
http://dx.doi.org/10.12717/DR.2020.24.2.89
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author Jang, Mi Gyeong
Song, Hana
Kim, Ji Hye
Oh, Jung Min
Park, Jung Young
Ko, Hee Chul
Hur, Sung-Pyo
Kim, Se-Jae
author_facet Jang, Mi Gyeong
Song, Hana
Kim, Ji Hye
Oh, Jung Min
Park, Jung Young
Ko, Hee Chul
Hur, Sung-Pyo
Kim, Se-Jae
author_sort Jang, Mi Gyeong
collection PubMed
description Clerodendrum trichotomum is a folk medicine exhibiting anti-hypertension, anti-arthritis, and anti-rheumatism properties. However, little is known about whether the material might prevent hyperuricemia and associated inflammation. In this study, we explored whether C. trichotomum leaf extract (CTE) prevented hyperuricemia induced by potassium oxonate (PO) in mice. CTE (400 mg/kg body weight) significantly reduced the serum uric acid (UA), blood urea nitrogen (BUN), and serum creatinine levels and increased urine UA and creatinine levels. CTE ameliorated PO-induced inflammation and apoptosis by reducing the levels of relevant proteins in kidney tissues. Also, CTE ameliorated both UA-induced inflammatory response in RAW 263.7 cells and UA-induced cytotoxicity in HK-2 cells. In addition, liver transcriptome analysis showed that CTE enriched mainly the genes for mediating positive regulation of MAPK cascade and apoptotic signaling pathways. Together, the results show that CTE effectively prevents hyperuricemia and associated inflammation in PO-induced mice.
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spelling pubmed-73759802020-07-29 Prevention of Hyperuricemia by Clerodendrum trichotomum Leaf Extract in Potassium Oxonate-Induced Mice Jang, Mi Gyeong Song, Hana Kim, Ji Hye Oh, Jung Min Park, Jung Young Ko, Hee Chul Hur, Sung-Pyo Kim, Se-Jae Dev Reprod Research Article Clerodendrum trichotomum is a folk medicine exhibiting anti-hypertension, anti-arthritis, and anti-rheumatism properties. However, little is known about whether the material might prevent hyperuricemia and associated inflammation. In this study, we explored whether C. trichotomum leaf extract (CTE) prevented hyperuricemia induced by potassium oxonate (PO) in mice. CTE (400 mg/kg body weight) significantly reduced the serum uric acid (UA), blood urea nitrogen (BUN), and serum creatinine levels and increased urine UA and creatinine levels. CTE ameliorated PO-induced inflammation and apoptosis by reducing the levels of relevant proteins in kidney tissues. Also, CTE ameliorated both UA-induced inflammatory response in RAW 263.7 cells and UA-induced cytotoxicity in HK-2 cells. In addition, liver transcriptome analysis showed that CTE enriched mainly the genes for mediating positive regulation of MAPK cascade and apoptotic signaling pathways. Together, the results show that CTE effectively prevents hyperuricemia and associated inflammation in PO-induced mice. Korean Society of Developmental Biology 2020-06 2020-06-30 /pmc/articles/PMC7375980/ /pubmed/32734126 http://dx.doi.org/10.12717/DR.2020.24.2.89 Text en © Copyright 2020 The Korean Society of Developmental Biology http://creative-commons.org/licenses/by-nc/3.0/ This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creative-commons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jang, Mi Gyeong
Song, Hana
Kim, Ji Hye
Oh, Jung Min
Park, Jung Young
Ko, Hee Chul
Hur, Sung-Pyo
Kim, Se-Jae
Prevention of Hyperuricemia by Clerodendrum trichotomum Leaf Extract in Potassium Oxonate-Induced Mice
title Prevention of Hyperuricemia by Clerodendrum trichotomum Leaf Extract in Potassium Oxonate-Induced Mice
title_full Prevention of Hyperuricemia by Clerodendrum trichotomum Leaf Extract in Potassium Oxonate-Induced Mice
title_fullStr Prevention of Hyperuricemia by Clerodendrum trichotomum Leaf Extract in Potassium Oxonate-Induced Mice
title_full_unstemmed Prevention of Hyperuricemia by Clerodendrum trichotomum Leaf Extract in Potassium Oxonate-Induced Mice
title_short Prevention of Hyperuricemia by Clerodendrum trichotomum Leaf Extract in Potassium Oxonate-Induced Mice
title_sort prevention of hyperuricemia by clerodendrum trichotomum leaf extract in potassium oxonate-induced mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375980/
https://www.ncbi.nlm.nih.gov/pubmed/32734126
http://dx.doi.org/10.12717/DR.2020.24.2.89
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