Insulin2(Q104del) (Kuma) mutant mice develop diabetes with dominant inheritance

Insulin gene mutations have been identified to cause monogenic diabetes, and most of which developed permanent neonatal diabetes at young ages before 6 months of age in humans. To establish an animal model of permanent diabetes, we performed genome editing using the CRISPR/Cas9 system. We generated...

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Detalles Bibliográficos
Autores principales: Sakano, Daisuke, Inoue, Airi, Enomoto, Takayuki, Imasaka, Mai, Okada, Seiji, Yokota, Mutsumi, Koike, Masato, Araki, Kimi, Kume, Shoen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376009/
https://www.ncbi.nlm.nih.gov/pubmed/32699230
http://dx.doi.org/10.1038/s41598-020-68987-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376009/
https://www.ncbi.nlm.nih.gov/pubmed/32699230
http://dx.doi.org/10.1038/s41598-020-68987-z

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