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Insulin2(Q104del) (Kuma) mutant mice develop diabetes with dominant inheritance
Insulin gene mutations have been identified to cause monogenic diabetes, and most of which developed permanent neonatal diabetes at young ages before 6 months of age in humans. To establish an animal model of permanent diabetes, we performed genome editing using the CRISPR/Cas9 system. We generated...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376009/ https://www.ncbi.nlm.nih.gov/pubmed/32699230 http://dx.doi.org/10.1038/s41598-020-68987-z |