Combining triptolide with ABT-199 is effective against acute myeloid leukemia through reciprocal regulation of Bcl-2 family proteins and activation of the intrinsic apoptotic pathway

Bcl-2 inhibitors display an effective activity in acute myeloid leukemia (AML), but its clinical efficacy as a monotherapy was limited in part owing to failure to target other antiapoptotic Bcl-2 family proteins, such as Mcl-1. In this context, the combination strategy may be a promising approach to...

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Detalles Bibliográficos
Autores principales: Shi, Yuan-Fei, Liu, Long, He, Ling-Li, Ye, Jing, Lin, Zhi-Juan, Yuan, De-Lin, Deng, Man-Man, Fang, Zhi-Hong, Carter, Bing Z., Xu, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376040/
https://www.ncbi.nlm.nih.gov/pubmed/32699295
http://dx.doi.org/10.1038/s41419-020-02762-w

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