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Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study
Tinnitus has been implied as a “soft” sign of neurodegenerative disease, which is characterized by progressive loss of neuronal function, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). This study aimed to determine whether the risk of developing AD/PD increases after having tinnitus....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376045/ https://www.ncbi.nlm.nih.gov/pubmed/32699252 http://dx.doi.org/10.1038/s41598-020-69243-0 |
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author | Chu, Hsuan-Te Liang, Chih‐Sung Yeh, Ta-Chuan Hu, Li-Yu Yang, Albert C. Tsai, Shih-Jen Shen, Cheng-Che |
author_facet | Chu, Hsuan-Te Liang, Chih‐Sung Yeh, Ta-Chuan Hu, Li-Yu Yang, Albert C. Tsai, Shih-Jen Shen, Cheng-Che |
author_sort | Chu, Hsuan-Te |
collection | PubMed |
description | Tinnitus has been implied as a “soft” sign of neurodegenerative disease, which is characterized by progressive loss of neuronal function, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). This study aimed to determine whether the risk of developing AD/PD increases after having tinnitus. We conducted a retrospective matched cohort study with 12,657 tinnitus patients and 25,314 controls from the National Health Insurance Research Database (NHIRD) in Taiwan with almost 10 years follow-up. Tinnitus-related risk on developing AD/PD followingly was determined by the Cox regression to identify potential confounding factors. Through the 10-year follow-up period, 398 individuals with tinnitus (3.1%) and 501 control individuals (2.0%) developed AD (P < 0.001), and 211 tinnitus patients (1.7%) and 249 control patients (1.0%) developed PD (P < 0.001). Compared with controls, patients with tinnitus were 1.54 times more likely to develop AD (95% confidence interval (CI) 1.34–1.78, P < 0.001) and 1.56 times more likely to develop PD (95% CI 1.29–1.89, P < 0.001), after adjusting confounding factors. Our results indicate an association between tinnitus and higher risk of developing AD and PD. Additional physical comorbidities may also increase the risk of developing AD and PD. |
format | Online Article Text |
id | pubmed-7376045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73760452020-07-24 Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study Chu, Hsuan-Te Liang, Chih‐Sung Yeh, Ta-Chuan Hu, Li-Yu Yang, Albert C. Tsai, Shih-Jen Shen, Cheng-Che Sci Rep Article Tinnitus has been implied as a “soft” sign of neurodegenerative disease, which is characterized by progressive loss of neuronal function, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). This study aimed to determine whether the risk of developing AD/PD increases after having tinnitus. We conducted a retrospective matched cohort study with 12,657 tinnitus patients and 25,314 controls from the National Health Insurance Research Database (NHIRD) in Taiwan with almost 10 years follow-up. Tinnitus-related risk on developing AD/PD followingly was determined by the Cox regression to identify potential confounding factors. Through the 10-year follow-up period, 398 individuals with tinnitus (3.1%) and 501 control individuals (2.0%) developed AD (P < 0.001), and 211 tinnitus patients (1.7%) and 249 control patients (1.0%) developed PD (P < 0.001). Compared with controls, patients with tinnitus were 1.54 times more likely to develop AD (95% confidence interval (CI) 1.34–1.78, P < 0.001) and 1.56 times more likely to develop PD (95% CI 1.29–1.89, P < 0.001), after adjusting confounding factors. Our results indicate an association between tinnitus and higher risk of developing AD and PD. Additional physical comorbidities may also increase the risk of developing AD and PD. Nature Publishing Group UK 2020-07-22 /pmc/articles/PMC7376045/ /pubmed/32699252 http://dx.doi.org/10.1038/s41598-020-69243-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Chu, Hsuan-Te Liang, Chih‐Sung Yeh, Ta-Chuan Hu, Li-Yu Yang, Albert C. Tsai, Shih-Jen Shen, Cheng-Che Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study |
title | Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study |
title_full | Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study |
title_fullStr | Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study |
title_full_unstemmed | Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study |
title_short | Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study |
title_sort | tinnitus and risk of alzheimer’s and parkinson’s disease: a retrospective nationwide population-based cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376045/ https://www.ncbi.nlm.nih.gov/pubmed/32699252 http://dx.doi.org/10.1038/s41598-020-69243-0 |
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