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Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study
OBJECTIVE: The present in vitro study investigated if simulated daily use of hydroxyapatite-based gel (15% HAP) remineralizes early caries lesions as effective as weekly use of high fluoride (12,500 ppm) concentration gel, comparing them with artificial saliva alone. MATERIALS AND METHODS: Three too...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376056/ https://www.ncbi.nlm.nih.gov/pubmed/32714565 http://dx.doi.org/10.1038/s41405-020-0037-5 |
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author | Amaechi, Bennett T. AbdulAzees, Parveez Ahamed Okoye, Linda O. Meyer, Frederic Enax, Joachim |
author_facet | Amaechi, Bennett T. AbdulAzees, Parveez Ahamed Okoye, Linda O. Meyer, Frederic Enax, Joachim |
author_sort | Amaechi, Bennett T. |
collection | PubMed |
description | OBJECTIVE: The present in vitro study investigated if simulated daily use of hydroxyapatite-based gel (15% HAP) remineralizes early caries lesions as effective as weekly use of high fluoride (12,500 ppm) concentration gel, comparing them with artificial saliva alone. MATERIALS AND METHODS: Three tooth blocks were produced from each of 20 bovine teeth. Caries-like lesion was created on each block by 4-day demineralization in acidified gel. The blocks were randomized into three remineralization groups (20 blocks/group); Hydroxyapatite-based gel (Karex gelée, 15% HAP, fluoride-free), fluoride-based gel (Elmex gelée, 12,500 ppm F(−)), and artificial saliva (AS). Remineralization was conducted using pH-cycling model for 28 days with storage in AS. The pH cycling model consisted of 2 h demineralization once daily for all groups, and 3 min HAP gel application once daily, 3 min fluoride gel application once weekly, or remain in AS only respectively. Baseline and post-test mineral loss were quantified using microradiography. RESULTS: Paired t-tests (baseline vs. post-Test) indicated significant (p < 0.0001) remineralization in all groups. When compared against each other using Games-Howell’s multiple comparison test, no significant difference in remineralization was observed between the two gels, but both gels exhibited significantly (p < 0.001) higher percentage mineral gain (HAP:39 ± 7%; fluoride:41 ± 11%) than AS alone (6 ± 2%). CONCLUSION: Hydroxyapatite-based gel (15% HAP) was as effective as fluoride-based gel (12,500 ppm F(−)) in remineralizing initial caries lesion. |
format | Online Article Text |
id | pubmed-7376056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73760562020-07-24 Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study Amaechi, Bennett T. AbdulAzees, Parveez Ahamed Okoye, Linda O. Meyer, Frederic Enax, Joachim BDJ Open Article OBJECTIVE: The present in vitro study investigated if simulated daily use of hydroxyapatite-based gel (15% HAP) remineralizes early caries lesions as effective as weekly use of high fluoride (12,500 ppm) concentration gel, comparing them with artificial saliva alone. MATERIALS AND METHODS: Three tooth blocks were produced from each of 20 bovine teeth. Caries-like lesion was created on each block by 4-day demineralization in acidified gel. The blocks were randomized into three remineralization groups (20 blocks/group); Hydroxyapatite-based gel (Karex gelée, 15% HAP, fluoride-free), fluoride-based gel (Elmex gelée, 12,500 ppm F(−)), and artificial saliva (AS). Remineralization was conducted using pH-cycling model for 28 days with storage in AS. The pH cycling model consisted of 2 h demineralization once daily for all groups, and 3 min HAP gel application once daily, 3 min fluoride gel application once weekly, or remain in AS only respectively. Baseline and post-test mineral loss were quantified using microradiography. RESULTS: Paired t-tests (baseline vs. post-Test) indicated significant (p < 0.0001) remineralization in all groups. When compared against each other using Games-Howell’s multiple comparison test, no significant difference in remineralization was observed between the two gels, but both gels exhibited significantly (p < 0.001) higher percentage mineral gain (HAP:39 ± 7%; fluoride:41 ± 11%) than AS alone (6 ± 2%). CONCLUSION: Hydroxyapatite-based gel (15% HAP) was as effective as fluoride-based gel (12,500 ppm F(−)) in remineralizing initial caries lesion. Nature Publishing Group UK 2020-07-22 /pmc/articles/PMC7376056/ /pubmed/32714565 http://dx.doi.org/10.1038/s41405-020-0037-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Amaechi, Bennett T. AbdulAzees, Parveez Ahamed Okoye, Linda O. Meyer, Frederic Enax, Joachim Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study |
title | Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study |
title_full | Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study |
title_fullStr | Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study |
title_full_unstemmed | Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study |
title_short | Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study |
title_sort | comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a ph-cycling study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376056/ https://www.ncbi.nlm.nih.gov/pubmed/32714565 http://dx.doi.org/10.1038/s41405-020-0037-5 |
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