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Vitamin D protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice

Vitamin D deficiency is a recognized risk factor for sarcopenia development, but mechanisms underlying this outcome are unclear. Here, we show that low vitamin D status worsens immobilization-induced muscle atrophy in mice. Mice globally lacking vitamin D receptor (VDR) exhibited more severe muscle...

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Detalles Bibliográficos
Autores principales: Nakamura, Satoshi, Sato, Yuiko, Kobayashi, Tami, Kaneko, Yosuke, Ito, Eri, Soma, Tomoya, Okada, Hiroyuki, Miyamoto, Kana, Oya, Akihito, Matsumoto, Morio, Nakamura, Masaya, Kanaji, Arihiko, Miyamoto, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376070/
https://www.ncbi.nlm.nih.gov/pubmed/32699341
http://dx.doi.org/10.1038/s41598-020-69021-y
Descripción
Sumario:Vitamin D deficiency is a recognized risk factor for sarcopenia development, but mechanisms underlying this outcome are unclear. Here, we show that low vitamin D status worsens immobilization-induced muscle atrophy in mice. Mice globally lacking vitamin D receptor (VDR) exhibited more severe muscle atrophy following limb immobilization than controls. Moreover, immobilization-induced muscle atrophy was worse in neural crest-specific than in skeletal muscle-specific VDR-deficient mice. Tnfα expression was significantly higher in immobilized muscle of VDR-deficient relative to control mice, and was significantly elevated in neural crest-specific but not muscle-specific VDR-deficient mice. Furthermore, muscle atrophy induced by limb immobilization in low vitamin D mice was significantly inhibited in Tnfα-deficient mice. We conclude that vitamin D antagonizes immobilization-induced muscle atrophy via VDR expressed in neural crest-derived cells.