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Vitamin D protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice
Vitamin D deficiency is a recognized risk factor for sarcopenia development, but mechanisms underlying this outcome are unclear. Here, we show that low vitamin D status worsens immobilization-induced muscle atrophy in mice. Mice globally lacking vitamin D receptor (VDR) exhibited more severe muscle...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376070/ https://www.ncbi.nlm.nih.gov/pubmed/32699341 http://dx.doi.org/10.1038/s41598-020-69021-y |
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author | Nakamura, Satoshi Sato, Yuiko Kobayashi, Tami Kaneko, Yosuke Ito, Eri Soma, Tomoya Okada, Hiroyuki Miyamoto, Kana Oya, Akihito Matsumoto, Morio Nakamura, Masaya Kanaji, Arihiko Miyamoto, Takeshi |
author_facet | Nakamura, Satoshi Sato, Yuiko Kobayashi, Tami Kaneko, Yosuke Ito, Eri Soma, Tomoya Okada, Hiroyuki Miyamoto, Kana Oya, Akihito Matsumoto, Morio Nakamura, Masaya Kanaji, Arihiko Miyamoto, Takeshi |
author_sort | Nakamura, Satoshi |
collection | PubMed |
description | Vitamin D deficiency is a recognized risk factor for sarcopenia development, but mechanisms underlying this outcome are unclear. Here, we show that low vitamin D status worsens immobilization-induced muscle atrophy in mice. Mice globally lacking vitamin D receptor (VDR) exhibited more severe muscle atrophy following limb immobilization than controls. Moreover, immobilization-induced muscle atrophy was worse in neural crest-specific than in skeletal muscle-specific VDR-deficient mice. Tnfα expression was significantly higher in immobilized muscle of VDR-deficient relative to control mice, and was significantly elevated in neural crest-specific but not muscle-specific VDR-deficient mice. Furthermore, muscle atrophy induced by limb immobilization in low vitamin D mice was significantly inhibited in Tnfα-deficient mice. We conclude that vitamin D antagonizes immobilization-induced muscle atrophy via VDR expressed in neural crest-derived cells. |
format | Online Article Text |
id | pubmed-7376070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73760702020-07-24 Vitamin D protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice Nakamura, Satoshi Sato, Yuiko Kobayashi, Tami Kaneko, Yosuke Ito, Eri Soma, Tomoya Okada, Hiroyuki Miyamoto, Kana Oya, Akihito Matsumoto, Morio Nakamura, Masaya Kanaji, Arihiko Miyamoto, Takeshi Sci Rep Article Vitamin D deficiency is a recognized risk factor for sarcopenia development, but mechanisms underlying this outcome are unclear. Here, we show that low vitamin D status worsens immobilization-induced muscle atrophy in mice. Mice globally lacking vitamin D receptor (VDR) exhibited more severe muscle atrophy following limb immobilization than controls. Moreover, immobilization-induced muscle atrophy was worse in neural crest-specific than in skeletal muscle-specific VDR-deficient mice. Tnfα expression was significantly higher in immobilized muscle of VDR-deficient relative to control mice, and was significantly elevated in neural crest-specific but not muscle-specific VDR-deficient mice. Furthermore, muscle atrophy induced by limb immobilization in low vitamin D mice was significantly inhibited in Tnfα-deficient mice. We conclude that vitamin D antagonizes immobilization-induced muscle atrophy via VDR expressed in neural crest-derived cells. Nature Publishing Group UK 2020-07-22 /pmc/articles/PMC7376070/ /pubmed/32699341 http://dx.doi.org/10.1038/s41598-020-69021-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Nakamura, Satoshi Sato, Yuiko Kobayashi, Tami Kaneko, Yosuke Ito, Eri Soma, Tomoya Okada, Hiroyuki Miyamoto, Kana Oya, Akihito Matsumoto, Morio Nakamura, Masaya Kanaji, Arihiko Miyamoto, Takeshi Vitamin D protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice |
title | Vitamin D protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice |
title_full | Vitamin D protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice |
title_fullStr | Vitamin D protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice |
title_full_unstemmed | Vitamin D protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice |
title_short | Vitamin D protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice |
title_sort | vitamin d protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376070/ https://www.ncbi.nlm.nih.gov/pubmed/32699341 http://dx.doi.org/10.1038/s41598-020-69021-y |
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