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Morin attenuates STZ-induced diabetic retinopathy in experimental animals

Diabetic retinopathy (DR) occurs in untreated diabetic patients due to the strong influence of oxidative stress. Bioflavonoids are well known for their antioxidant property. Morin, a bioflavonoid, has been demonstrated for its antioxidant as well as antidiabetic activity. Thus, this research work in...

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Autores principales: Jiang, Bo, Geng, Qingsen, Li, Tao, Mohammad Firdous, Sayeed, Zhou, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376113/
https://www.ncbi.nlm.nih.gov/pubmed/32714041
http://dx.doi.org/10.1016/j.sjbs.2020.06.001
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author Jiang, Bo
Geng, Qingsen
Li, Tao
Mohammad Firdous, Sayeed
Zhou, Xiaodong
author_facet Jiang, Bo
Geng, Qingsen
Li, Tao
Mohammad Firdous, Sayeed
Zhou, Xiaodong
author_sort Jiang, Bo
collection PubMed
description Diabetic retinopathy (DR) occurs in untreated diabetic patients due to the strong influence of oxidative stress. Bioflavonoids are well known for their antioxidant property. Morin, a bioflavonoid, has been demonstrated for its antioxidant as well as antidiabetic activity. Thus, this research work intended to determine the ameliorative impact of morin in DR rats using STZ-induced type 1 diabetic model. To induce type 1 diabetic in rats STZ (60 mg/kg) was administered intraperitoneally. Grouping of animals was done as described below (n = 6), where, group I – normal control, group II – diabetic control, group III – morin (25 mg/kg), group IV – morin (50 mg/kg), and group V – metformin (350 mg/kg) were used. All the animals underwent treatment for 60 days as given above. It was observed that supplementation of morin (25 and 50 mg/kg) showed a noteworthy decline in elevated serum glucose level. Moreover, decrease in the level of LPO and improved activity of endogenous antioxidants (GPx, CAT, and SOD) was observed in morin treated groups. It also notably drops the concentration of TNF-α, IL-1β, and VEGF in the tissue homogenate of the retina. Furthermore, it increased the retinal thickness and cell count in the ganglion cell layer of the retina in diabetic animals. Hence, we can conclude that morin encumbers the progression of DR in diabetic animals, which may be via antioxidant property and suppression of TNF-α, IL-1β, and VEGF.
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spelling pubmed-73761132020-07-23 Morin attenuates STZ-induced diabetic retinopathy in experimental animals Jiang, Bo Geng, Qingsen Li, Tao Mohammad Firdous, Sayeed Zhou, Xiaodong Saudi J Biol Sci Article Diabetic retinopathy (DR) occurs in untreated diabetic patients due to the strong influence of oxidative stress. Bioflavonoids are well known for their antioxidant property. Morin, a bioflavonoid, has been demonstrated for its antioxidant as well as antidiabetic activity. Thus, this research work intended to determine the ameliorative impact of morin in DR rats using STZ-induced type 1 diabetic model. To induce type 1 diabetic in rats STZ (60 mg/kg) was administered intraperitoneally. Grouping of animals was done as described below (n = 6), where, group I – normal control, group II – diabetic control, group III – morin (25 mg/kg), group IV – morin (50 mg/kg), and group V – metformin (350 mg/kg) were used. All the animals underwent treatment for 60 days as given above. It was observed that supplementation of morin (25 and 50 mg/kg) showed a noteworthy decline in elevated serum glucose level. Moreover, decrease in the level of LPO and improved activity of endogenous antioxidants (GPx, CAT, and SOD) was observed in morin treated groups. It also notably drops the concentration of TNF-α, IL-1β, and VEGF in the tissue homogenate of the retina. Furthermore, it increased the retinal thickness and cell count in the ganglion cell layer of the retina in diabetic animals. Hence, we can conclude that morin encumbers the progression of DR in diabetic animals, which may be via antioxidant property and suppression of TNF-α, IL-1β, and VEGF. Elsevier 2020-08 2020-06-08 /pmc/articles/PMC7376113/ /pubmed/32714041 http://dx.doi.org/10.1016/j.sjbs.2020.06.001 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Jiang, Bo
Geng, Qingsen
Li, Tao
Mohammad Firdous, Sayeed
Zhou, Xiaodong
Morin attenuates STZ-induced diabetic retinopathy in experimental animals
title Morin attenuates STZ-induced diabetic retinopathy in experimental animals
title_full Morin attenuates STZ-induced diabetic retinopathy in experimental animals
title_fullStr Morin attenuates STZ-induced diabetic retinopathy in experimental animals
title_full_unstemmed Morin attenuates STZ-induced diabetic retinopathy in experimental animals
title_short Morin attenuates STZ-induced diabetic retinopathy in experimental animals
title_sort morin attenuates stz-induced diabetic retinopathy in experimental animals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376113/
https://www.ncbi.nlm.nih.gov/pubmed/32714041
http://dx.doi.org/10.1016/j.sjbs.2020.06.001
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