Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma

Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to delineate the methylome landscape and characterize the oncogenic drivers of esophageal squamous cell carcinoma (ESCC). We found 98% of CpGs are hypomethylated across the ES...

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Detalles Bibliográficos
Autores principales: Cao, Wei, Lee, Hayan, Wu, Wei, Zaman, Aubhishek, McCorkle, Sean, Yan, Ming, Chen, Justin, Xing, Qinghe, Sinnott-Armstrong, Nasa, Xu, Hongen, Sailani, M. Reza, Tang, Wenxue, Cui, Yuanbo, liu, Jia, Guan, Hongyan, Lv, Pengju, Sun, Xiaoyan, Sun, Lei, Han, Pengli, Lou, Yanan, Chang, Jing, Wang, Jinwu, Gao, Yuchi, Guo, Jiancheng, Schenk, Gundolf, Shain, Alan Hunter, Biddle, Fred G., Collisson, Eric, Snyder, Michael, Bivona, Trever G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376194/
https://www.ncbi.nlm.nih.gov/pubmed/32699215
http://dx.doi.org/10.1038/s41467-020-17227-z

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