Population Pharmacodynamic Model of Neutrophil Margination and Tolerance to Describe Effect of Sarilumab on Absolute Neutrophil Count in Patients with Rheumatoid Arthritis

Evidence suggests that effects of interleukin‐6 pathway inhibitors sarilumab, tocilizumab, and sirukumab on absolute neutrophil count (ANC) are due to margination of circulating neutrophils into rapidly mobilizable noncirculating pools. We developed a population pharmacodynamic model using compartme...

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Detalles Bibliográficos
Autores principales: Kovalenko, Pavel, Paccaly, Anne, Boyapati, Anita, Xu, Christine, St John, Gregory, Nivens, Michael C., Davis, John D., Rippley, Ronda, DiCioccio, A. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376291/
https://www.ncbi.nlm.nih.gov/pubmed/32453485
http://dx.doi.org/10.1002/psp4.12534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376291/
https://www.ncbi.nlm.nih.gov/pubmed/32453485
http://dx.doi.org/10.1002/psp4.12534

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