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Exploring concomitant neuroimaging and genetic alterations in patients with and patients without auditory verbal hallucinations: A pilot study and mini review

OBJECTIVE: To explore concomitant neuroimaging and genetic alterations in patients with schizophrenia with or without auditory verbal hallucinations (AVHs), and to discuss the use of pattern recognition techniques in the development of an objective index that may improve diagnostic accuracy and trea...

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Autores principales: Yu, Haiping, Ying, Wang, Li, Gang, Lin, Xiaodong, Jiang, Deguo, Chen, Guangdong, Chen, Suling, Sun, Xiuhai, Xu, Yong, Ye, Jiaen, Zhuo, Chuanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376300/
https://www.ncbi.nlm.nih.gov/pubmed/32696690
http://dx.doi.org/10.1177/0300060519884856
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author Yu, Haiping
Ying, Wang
Li, Gang
Lin, Xiaodong
Jiang, Deguo
Chen, Guangdong
Chen, Suling
Sun, Xiuhai
Xu, Yong
Ye, Jiaen
Zhuo, Chuanjun
author_facet Yu, Haiping
Ying, Wang
Li, Gang
Lin, Xiaodong
Jiang, Deguo
Chen, Guangdong
Chen, Suling
Sun, Xiuhai
Xu, Yong
Ye, Jiaen
Zhuo, Chuanjun
author_sort Yu, Haiping
collection PubMed
description OBJECTIVE: To explore concomitant neuroimaging and genetic alterations in patients with schizophrenia with or without auditory verbal hallucinations (AVHs), and to discuss the use of pattern recognition techniques in the development of an objective index that may improve diagnostic accuracy and treatment outcomes for schizophrenia. METHODS: The pilot study included patients with schizophrenia with AVHs (SCH-AVH group) and without AVHs (SCH-no AVH group). High throughput sequencing (HTS) was performed to explore RNA networks. Global functional connectivity density (gFCD) analysis was performed to assess functional connectivity (FC) alterations of the default mode network (DMN). Quantitative long noncoding (lnc) RNA and mRNA expression data were related to peak T values of gFCDs using Pearson’s correlation coefficient analysis. RESULTS: Compared with the SCH-no AVH group (n = 5), patients in the SCH-AVH group (n = 5) exhibited differences in RNA expression in RNA networks that were related to AVH severity, and displayed alterations in FC (reflected by gFCD differences) within the DMN (posterior cingulate and dorsal-medial prefrontal cortex), and in the right parietal lobe, left occipital lobe, and left temporal lobe. Peak lncRNA expression values were significantly related to peak gFCD T values within the DMN. CONCLUSION: Among patients with schizophrenia, there are concomitant FC and genetic expression alterations associated with AVHs. Data from pattern recognition studies may inform the development of an objective index aimed at improving early diagnostic accuracy and treatment planning for patients with schizophrenia with and without AVHs.
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spelling pubmed-73763002020-07-31 Exploring concomitant neuroimaging and genetic alterations in patients with and patients without auditory verbal hallucinations: A pilot study and mini review Yu, Haiping Ying, Wang Li, Gang Lin, Xiaodong Jiang, Deguo Chen, Guangdong Chen, Suling Sun, Xiuhai Xu, Yong Ye, Jiaen Zhuo, Chuanjun J Int Med Res Review OBJECTIVE: To explore concomitant neuroimaging and genetic alterations in patients with schizophrenia with or without auditory verbal hallucinations (AVHs), and to discuss the use of pattern recognition techniques in the development of an objective index that may improve diagnostic accuracy and treatment outcomes for schizophrenia. METHODS: The pilot study included patients with schizophrenia with AVHs (SCH-AVH group) and without AVHs (SCH-no AVH group). High throughput sequencing (HTS) was performed to explore RNA networks. Global functional connectivity density (gFCD) analysis was performed to assess functional connectivity (FC) alterations of the default mode network (DMN). Quantitative long noncoding (lnc) RNA and mRNA expression data were related to peak T values of gFCDs using Pearson’s correlation coefficient analysis. RESULTS: Compared with the SCH-no AVH group (n = 5), patients in the SCH-AVH group (n = 5) exhibited differences in RNA expression in RNA networks that were related to AVH severity, and displayed alterations in FC (reflected by gFCD differences) within the DMN (posterior cingulate and dorsal-medial prefrontal cortex), and in the right parietal lobe, left occipital lobe, and left temporal lobe. Peak lncRNA expression values were significantly related to peak gFCD T values within the DMN. CONCLUSION: Among patients with schizophrenia, there are concomitant FC and genetic expression alterations associated with AVHs. Data from pattern recognition studies may inform the development of an objective index aimed at improving early diagnostic accuracy and treatment planning for patients with schizophrenia with and without AVHs. SAGE Publications 2020-07-22 /pmc/articles/PMC7376300/ /pubmed/32696690 http://dx.doi.org/10.1177/0300060519884856 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Yu, Haiping
Ying, Wang
Li, Gang
Lin, Xiaodong
Jiang, Deguo
Chen, Guangdong
Chen, Suling
Sun, Xiuhai
Xu, Yong
Ye, Jiaen
Zhuo, Chuanjun
Exploring concomitant neuroimaging and genetic alterations in patients with and patients without auditory verbal hallucinations: A pilot study and mini review
title Exploring concomitant neuroimaging and genetic alterations in patients with and patients without auditory verbal hallucinations: A pilot study and mini review
title_full Exploring concomitant neuroimaging and genetic alterations in patients with and patients without auditory verbal hallucinations: A pilot study and mini review
title_fullStr Exploring concomitant neuroimaging and genetic alterations in patients with and patients without auditory verbal hallucinations: A pilot study and mini review
title_full_unstemmed Exploring concomitant neuroimaging and genetic alterations in patients with and patients without auditory verbal hallucinations: A pilot study and mini review
title_short Exploring concomitant neuroimaging and genetic alterations in patients with and patients without auditory verbal hallucinations: A pilot study and mini review
title_sort exploring concomitant neuroimaging and genetic alterations in patients with and patients without auditory verbal hallucinations: a pilot study and mini review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376300/
https://www.ncbi.nlm.nih.gov/pubmed/32696690
http://dx.doi.org/10.1177/0300060519884856
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