De novo thymic carcinoma or malignant transformation: a myasthenic patient presented with multiple mediastinal tumours

A 63‐year‐old man presented with bilateral ptosis, and detailed evaluation confirmed ocular myasthenia gravis with three anterior mediastinal masses on computed tomography (CT) of the chest. Extended thymectomy was performed, and pathology revealed two thymic carcinoma and one thymoma. After surgery...

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Autores principales: Pai, Chu‐Pin, Lin, Chih‐Ming, Yeh, Yi‐Chen, Huang, Chien‐Sheng, Huang, Biing‐Shiun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376331/
https://www.ncbi.nlm.nih.gov/pubmed/32714553
http://dx.doi.org/10.1002/rcr2.629
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author Pai, Chu‐Pin
Lin, Chih‐Ming
Yeh, Yi‐Chen
Huang, Chien‐Sheng
Huang, Biing‐Shiun
author_facet Pai, Chu‐Pin
Lin, Chih‐Ming
Yeh, Yi‐Chen
Huang, Chien‐Sheng
Huang, Biing‐Shiun
author_sort Pai, Chu‐Pin
collection PubMed
description A 63‐year‐old man presented with bilateral ptosis, and detailed evaluation confirmed ocular myasthenia gravis with three anterior mediastinal masses on computed tomography (CT) of the chest. Extended thymectomy was performed, and pathology revealed two thymic carcinoma and one thymoma. After surgery, the patient is free from recurrence. Synchronous triple thymic carcinomas and thymoma have not been reported. The finding of this case report supports the hypothesis of malignant transformation of thymoma to thymic carcinoma. Thymic carcinoma should be considered in the differential diagnosis of multiple thymic tumours, and extended thymectomy should be the treatment of choice.
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spelling pubmed-73763312020-07-23 De novo thymic carcinoma or malignant transformation: a myasthenic patient presented with multiple mediastinal tumours Pai, Chu‐Pin Lin, Chih‐Ming Yeh, Yi‐Chen Huang, Chien‐Sheng Huang, Biing‐Shiun Respirol Case Rep Case Reports A 63‐year‐old man presented with bilateral ptosis, and detailed evaluation confirmed ocular myasthenia gravis with three anterior mediastinal masses on computed tomography (CT) of the chest. Extended thymectomy was performed, and pathology revealed two thymic carcinoma and one thymoma. After surgery, the patient is free from recurrence. Synchronous triple thymic carcinomas and thymoma have not been reported. The finding of this case report supports the hypothesis of malignant transformation of thymoma to thymic carcinoma. Thymic carcinoma should be considered in the differential diagnosis of multiple thymic tumours, and extended thymectomy should be the treatment of choice. John Wiley & Sons, Ltd 2020-07-23 /pmc/articles/PMC7376331/ /pubmed/32714553 http://dx.doi.org/10.1002/rcr2.629 Text en © 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Pai, Chu‐Pin
Lin, Chih‐Ming
Yeh, Yi‐Chen
Huang, Chien‐Sheng
Huang, Biing‐Shiun
De novo thymic carcinoma or malignant transformation: a myasthenic patient presented with multiple mediastinal tumours
title De novo thymic carcinoma or malignant transformation: a myasthenic patient presented with multiple mediastinal tumours
title_full De novo thymic carcinoma or malignant transformation: a myasthenic patient presented with multiple mediastinal tumours
title_fullStr De novo thymic carcinoma or malignant transformation: a myasthenic patient presented with multiple mediastinal tumours
title_full_unstemmed De novo thymic carcinoma or malignant transformation: a myasthenic patient presented with multiple mediastinal tumours
title_short De novo thymic carcinoma or malignant transformation: a myasthenic patient presented with multiple mediastinal tumours
title_sort de novo thymic carcinoma or malignant transformation: a myasthenic patient presented with multiple mediastinal tumours
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376331/
https://www.ncbi.nlm.nih.gov/pubmed/32714553
http://dx.doi.org/10.1002/rcr2.629
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