Ginsenoside Rb1 Alleviated High-Fat-Diet-Induced Hepatocytic Apoptosis via Peroxisome Proliferator-Activated Receptor γ

OBJECTIVE: High-fat-diet- (HFD-) induced hepatic cell apoptosis is common in mice with nonalcoholic fatty liver disease (NAFLD). We aim to investigate the effect of Ginsenoside Rb1 (GRb1) on hepatocyte apoptosis. METHODS: C57BL/6J mice with HFD were used to induce a liver-injured model with cell apo...

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Detalles Bibliográficos
Autores principales: Song, Bing, Sun, Yao, Chu, Yafen, Wang, Jing, Zheng, Hongwei, Liu, Lili, Cai, Wang, Zhang, Haoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376403/
https://www.ncbi.nlm.nih.gov/pubmed/32733933
http://dx.doi.org/10.1155/2020/2315230
Descripción
Sumario:OBJECTIVE: High-fat-diet- (HFD-) induced hepatic cell apoptosis is common in mice with nonalcoholic fatty liver disease (NAFLD). We aim to investigate the effect of Ginsenoside Rb1 (GRb1) on hepatocyte apoptosis. METHODS: C57BL/6J mice with HFD were used to induce a liver-injured model with cell apoptosis. In addition, GRb1 was used to treat HFD-induced apoptosis in a liver with or without inhibitor of peroxisome proliferator-activated receptor γ (PPAR-γ). RESULTS: Compared with C57BL/6J mice with common chow, there are downregulated PPAR-γ but upregulated cell apoptosis in the liver of mice with HFD. Furthermore, GRb1 elevated the hepatic PPAR-γ level and suppressed hepatocytic apoptosis. However, GW9662 abolished the effects of GRb1 on apoptosis in the liver. CONCLUSIONS: GRb1 alleviated HFD-induced apoptosis of hepatocytes of mice via PPAR-γ.

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