Cargando…

SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes

Suppressor of cytokine signaling 2 (SOCS2) plays an important role in fat deposition, skeletal muscle, central nervous system development, and mitochondria biogenesis. Nevertheless, the regulatory mechanisms of SOCS2 on mitochondrial fatty acid oxidation (FAO) remain unclear. Leptin could inhibit fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Tiantian, Chen, Yizhe, Cai, Jiarui, Pan, Miao, Sun, Qian, Zhang, Jing, Sun, Chao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376435/ https://www.ncbi.nlm.nih.gov/pubmed/32733634 http://dx.doi.org/10.1155/2020/3742542

Ejemplares similares

Investigation of TCF7L2, LEP and LEPR polymorphisms with esophageal squamous cell carcinomas
por: Qiu, Hao, et al.
Publicado: (2017)

Relationship status update for PTP1B and LepR: It׳s complicated()
por: Fischer, Katrin, et al.
Publicado: (2014)

Effects of Isorhamnetin on Adipocyte Mitochondrial Biogenesis and AMPK Activation
por: Lee, Mak-Soon, et al.
Publicado: (2018)

Dysregulation of DPP4 Is Associated with the AMPK/JAK2/STAT3 Pathway in Adipocytes Under Insulin Resistance Status and Liraglutide Intervention
por: Cheng, Fangxiao, et al.
Publicado: (2019)

La Lepre
Publicado: (1934)

Disruption of JAK2 in Adipocytes Impairs Lipolysis and Improves Fatty Liver in Mice With Elevated GH
por: Nordstrom, Sarah M., et al.
Publicado: (2013)

The Influence of LepR Tyrosine Site Mutations on Mouse Ovary Development and Related Gene Expression Changes
por: Tu, Xiaoyu, et al.
Publicado: (2015)

EYA2 suppresses the progression of hepatocellular carcinoma via SOCS3-mediated blockade of JAK/STAT signaling
por: Liu, Ze-Kun, et al.
Publicado: (2021)

t(8;9)(p22;p24)/PCM1-JAK2 Activates SOCS2 and SOCS3 via STAT5
por: Ehrentraut, Stefan, et al.
Publicado: (2013)

The Expression of LEP, LEPR, IGF1 and IL10 in Obesity and the Relationship with microRNAs
por: Viesti A. Collares, Renata, et al.
Publicado: (2014)

The LepR-mediated leptin transport across brain barriers controls food reward
por: Di Spiezio, Alessandro, et al.
Publicado: (2017)

The molecular basis of JAK/STAT inhibition by SOCS1
por: Liau, Nicholas P. D., et al.
Publicado: (2018)

Co-localisation of the blackleg resistance genes Rlm2 and LepR3 on Brassica napus chromosome A10
por: Larkan, Nicholas J, et al.
Publicado: (2014)

Inhibition of JAK2/STAT3/SOCS3 signaling attenuates atherosclerosis in rabbit
por: Yang, Xilan, et al.
Publicado: (2020)

PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation
por: Yen, Yu-Ting, et al.
Publicado: (2021)

Association between polymorphisms of LEP, LEPR, DRD2, HTR2A and HTR2C genes and risperidone- or clozapine-induced hyperglycemia
por: Puangpetch, Apichaya, et al.
Publicado: (2019)

Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer
por: Marcello, Marjory Alana, et al.
Publicado: (2015)

Association of Single Nucleotide Polymorphisms in LEP, LEPR, and PPARG With Humoral Immune Response to Influenza Vaccine
por: Li, Mao, et al.
Publicado: (2021)

Association of PON1, LEP and LEPR Polymorphisms with Susceptibility to Breast Cancer: A Meta-Analysis
por: Sayad, Soheila, et al.
Publicado: (2021)

Associations of MC4R, LEP, and LEPR Polymorphisms with Obesity-Related Parameters in Childhood and Adulthood
por: Raskiliene, Asta, et al.
Publicado: (2021)

Identification of candidate genes for LepR1 resistance against Leptosphaeria maculans in Brassica napus
por: Cantila, Aldrin Y., et al.
Publicado: (2023)

Restoration of Lepr in β cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia
por: D'souza, Anna M., et al.
Publicado: (2017)

Ursolic Acid Inhibits Adipogenesis in 3T3-L1 Adipocytes through LKB1/AMPK Pathway
por: He, Yonghan, et al.
Publicado: (2013)

The Influence of FTO, FABP2, LEP, LEPR, and MC4R Genes on Obesity Parameters in Physically Active Caucasian Men
por: Maculewicz, Ewelina, et al.
Publicado: (2022)

SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis
por: Pandey, Rahul, et al.
Publicado: (2023)

Lidocaine alleviates morphine tolerance via AMPK-SOCS3-dependent neuroinflammation suppression in the spinal cord
por: Zhang, Yan, et al.
Publicado: (2017)

FABP4 reversed the regulation of leptin on mitochondrial fatty acid oxidation in mice adipocytes
por: Gan, Lu, et al.
Publicado: (2015)

SENP1 promotes MCL pathogenesis through regulating JAK-STAT5 pathway and SOCS2 expression
por: Zhang, Yali, et al.
Publicado: (2021)

Amyloid-β Induces Hepatic Insulin Resistance by Activating JAK2/STAT3/SOCS-1 Signaling Pathway
por: Zhang, Yi, et al.
Publicado: (2012)

Investigation of LEP and LEPR polymorphisms with the risk of hepatocellular carcinoma: a case–control study in Eastern Chinese Han population
por: Zhang, Sheng, et al.
Publicado: (2018)

Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity
por: Wunderlich, Claudia M., et al.
Publicado: (2013)

LncRNA KIAA0087 suppresses the progression of osteosarcoma by mediating the SOCS1/JAK2/STAT3 signaling pathway
por: Gong, Haoli, et al.
Publicado: (2023)

Farnesoid X receptor activation induces antitumour activity in colorectal cancer by suppressing JAK2/STAT3 signalling via transactivation of SOCS3 gene
por: Li, Shan, et al.
Publicado: (2020)

Inhibition of lncRNA DILC attenuates neuropathic pain via the SOCS3/JAK2/STAT3 pathway
por: Liu, Yujie, et al.
Publicado: (2020)

A Case of Congenital Hypopituitarism Associated With a 1p31 Microdeletion: A Possible Role for LEPR and JAK1
por: Thakur, Mili, et al.
Publicado: (2017)

Metformin Suppresses Diethylnitrosamine-Induced Liver Tumorigenesis in Obese and Diabetic C57BL/KsJ-+Lepr(db)/+Lepr(db) Mice
por: Ohno, Tomohiko, et al.
Publicado: (2015)

SOCS3 Promotes ALV-J Virus Replication via Inhibiting JAK2/STAT3 Phosphorylation During Infection
por: Mo, Guodong, et al.
Publicado: (2021)

Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Lepr(fa)/Lepr(fa) rat
por: Hattori, T, et al.
Publicado: (2011)

Transcriptional Insight Into Brassica napus Resistance Genes LepR3 and Rlm2-Mediated Defense Response Against the Leptosphaeria maculans Infection
por: Zhou, Tengsheng, et al.
Publicado: (2019)

Curcumin Suppressed Activation of Dendritic Cells via JAK/STAT/SOCS Signal in Mice with Experimental Colitis
por: Zhao, Hai-Mei, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ff0tv8rj61hdpcsd0opft57amc