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A Study on the Temporal Trends in the Etiology of Cirrhosis of Liver in Coastal Eastern Odisha
BACKGROUND: The etiology of cirrhosis of liver is known to change with time due to various factors including awareness, preventive interventions, and lifestyle changes in society. However, there is scarce Indian data available about temporal trends in etiology of cirrhosis of liver. Hence, the aim o...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Jaypee Brothers Medical Publishers
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376596/ https://www.ncbi.nlm.nih.gov/pubmed/32742964 http://dx.doi.org/10.5005/jp-journals-10018-1312 |
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author | Mishra, Debakanta Dash, Kaibalya R Khatua, Chittaranjan Panigrahi, Subhendu Parida, Prasanta K Behera, Sambit K Barik, Rakesh K Pradhan, Subhasis Sahu, Saroj K Thakur, Bhaskar Singh, Shivaram P |
author_facet | Mishra, Debakanta Dash, Kaibalya R Khatua, Chittaranjan Panigrahi, Subhendu Parida, Prasanta K Behera, Sambit K Barik, Rakesh K Pradhan, Subhasis Sahu, Saroj K Thakur, Bhaskar Singh, Shivaram P |
author_sort | Mishra, Debakanta |
collection | PubMed |
description | BACKGROUND: The etiology of cirrhosis of liver is known to change with time due to various factors including awareness, preventive interventions, and lifestyle changes in society. However, there is scarce Indian data available about temporal trends in etiology of cirrhosis of liver. Hence, the aim of this study was to study the temporal trends in the etiology of cirrhosis of liver. MATERIALS AND METHODS: This is a retrospective study conducted in the Department of Gastroenterology, Srirama Chandra Bhanja Medical College and Hospital, Cuttack, from January 2005 to December 2017. Data were collected from hospital records of all patients admitted to the Gastroenterology unit. A Poisson regression model was used to compare the hospitalization rate for different etiologies of cirrhosis of liver. All data were analyzed using Stata version 5.1 software. RESULTS: A total of 4,331 hospitalized patients of cirrhosis of liver were included in the analysis, of whom 2,742 (63.3%) had alcohol-related cirrhosis, 858 (19.8%) had viral hepatitis-related cirrhosis, and 731 (16.9%) had cirrhosis of liver due to nonalcohol and nonviral causes. The proportion of alcohol-related cirrhosis was increased by 26% from 2005 to 2017 (RR 1.26, p for trend <0.001). Though there were minimal ups and downs observed in the admission rate of viral hepatitis-related liver cirrhosis during later years, this was remarkably reduced by 73% (RR 0.27, p for trend <0.001) in the year 2017 at the end of the study. Similarly, the proportion of cirrhosis due to nonalcohol and nonviral causes decreased by 26% (RR 0.74, p for trend <0.001) by 2017. CONCLUSION: Alcohol is the most common cause of cirrhosis of liver and the burden of alcohol-related cirrhosis is significantly increasing in comparison to other causes including viral infection, nonalcoholic steatohepatitis (NASH), and autoimmune hepatitis. HOW TO CITE THIS ARTICLE: Mishra D, Dash KR, Khatua C, et al. A Study on the Temporal Trends in the Etiology of Cirrhosis of Liver in Coastal Eastern Odisha. Euroasian J Hepato-Gastroenterol 2020;10(1):1–6. |
format | Online Article Text |
id | pubmed-7376596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Jaypee Brothers Medical Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-73765962020-07-31 A Study on the Temporal Trends in the Etiology of Cirrhosis of Liver in Coastal Eastern Odisha Mishra, Debakanta Dash, Kaibalya R Khatua, Chittaranjan Panigrahi, Subhendu Parida, Prasanta K Behera, Sambit K Barik, Rakesh K Pradhan, Subhasis Sahu, Saroj K Thakur, Bhaskar Singh, Shivaram P Euroasian J Hepatogastroenterol Original Article BACKGROUND: The etiology of cirrhosis of liver is known to change with time due to various factors including awareness, preventive interventions, and lifestyle changes in society. However, there is scarce Indian data available about temporal trends in etiology of cirrhosis of liver. Hence, the aim of this study was to study the temporal trends in the etiology of cirrhosis of liver. MATERIALS AND METHODS: This is a retrospective study conducted in the Department of Gastroenterology, Srirama Chandra Bhanja Medical College and Hospital, Cuttack, from January 2005 to December 2017. Data were collected from hospital records of all patients admitted to the Gastroenterology unit. A Poisson regression model was used to compare the hospitalization rate for different etiologies of cirrhosis of liver. All data were analyzed using Stata version 5.1 software. RESULTS: A total of 4,331 hospitalized patients of cirrhosis of liver were included in the analysis, of whom 2,742 (63.3%) had alcohol-related cirrhosis, 858 (19.8%) had viral hepatitis-related cirrhosis, and 731 (16.9%) had cirrhosis of liver due to nonalcohol and nonviral causes. The proportion of alcohol-related cirrhosis was increased by 26% from 2005 to 2017 (RR 1.26, p for trend <0.001). Though there were minimal ups and downs observed in the admission rate of viral hepatitis-related liver cirrhosis during later years, this was remarkably reduced by 73% (RR 0.27, p for trend <0.001) in the year 2017 at the end of the study. Similarly, the proportion of cirrhosis due to nonalcohol and nonviral causes decreased by 26% (RR 0.74, p for trend <0.001) by 2017. CONCLUSION: Alcohol is the most common cause of cirrhosis of liver and the burden of alcohol-related cirrhosis is significantly increasing in comparison to other causes including viral infection, nonalcoholic steatohepatitis (NASH), and autoimmune hepatitis. HOW TO CITE THIS ARTICLE: Mishra D, Dash KR, Khatua C, et al. A Study on the Temporal Trends in the Etiology of Cirrhosis of Liver in Coastal Eastern Odisha. Euroasian J Hepato-Gastroenterol 2020;10(1):1–6. Jaypee Brothers Medical Publishers 2020 /pmc/articles/PMC7376596/ /pubmed/32742964 http://dx.doi.org/10.5005/jp-journals-10018-1312 Text en Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd. © The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Original Article Mishra, Debakanta Dash, Kaibalya R Khatua, Chittaranjan Panigrahi, Subhendu Parida, Prasanta K Behera, Sambit K Barik, Rakesh K Pradhan, Subhasis Sahu, Saroj K Thakur, Bhaskar Singh, Shivaram P A Study on the Temporal Trends in the Etiology of Cirrhosis of Liver in Coastal Eastern Odisha |
title | A Study on the Temporal Trends in the Etiology of Cirrhosis of Liver in Coastal Eastern Odisha |
title_full | A Study on the Temporal Trends in the Etiology of Cirrhosis of Liver in Coastal Eastern Odisha |
title_fullStr | A Study on the Temporal Trends in the Etiology of Cirrhosis of Liver in Coastal Eastern Odisha |
title_full_unstemmed | A Study on the Temporal Trends in the Etiology of Cirrhosis of Liver in Coastal Eastern Odisha |
title_short | A Study on the Temporal Trends in the Etiology of Cirrhosis of Liver in Coastal Eastern Odisha |
title_sort | study on the temporal trends in the etiology of cirrhosis of liver in coastal eastern odisha |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376596/ https://www.ncbi.nlm.nih.gov/pubmed/32742964 http://dx.doi.org/10.5005/jp-journals-10018-1312 |
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