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Variation in KSHV prevalence between geographically proximate locations in Uganda

Kaposi’s sarcoma-associated herpesvirus (KSHV) transmission within endemic areas may vary. KSHV seroprevalence has been studied by different groups of researchers using different methods, making it difficult to make direct comparisons. Here we show results on KSHV seroprevalence using the same labor...

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Autores principales: Nalwoga, Angela, Webb, Emily L., Muserere, Claudios, Chihota, Belinda, Miley, Wendell, Labo, Nazzarena, Elliott, Alison, Cose, Stephen, Whitby, Denise, Newton, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376633/
https://www.ncbi.nlm.nih.gov/pubmed/32714434
http://dx.doi.org/10.1186/s13027-020-00313-8
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author Nalwoga, Angela
Webb, Emily L.
Muserere, Claudios
Chihota, Belinda
Miley, Wendell
Labo, Nazzarena
Elliott, Alison
Cose, Stephen
Whitby, Denise
Newton, Robert
author_facet Nalwoga, Angela
Webb, Emily L.
Muserere, Claudios
Chihota, Belinda
Miley, Wendell
Labo, Nazzarena
Elliott, Alison
Cose, Stephen
Whitby, Denise
Newton, Robert
author_sort Nalwoga, Angela
collection PubMed
description Kaposi’s sarcoma-associated herpesvirus (KSHV) transmission within endemic areas may vary. KSHV seroprevalence has been studied by different groups of researchers using different methods, making it difficult to make direct comparisons. Here we show results on KSHV seroprevalence using the same laboratory method from four different but geographically proximate populations in Uganda. Blood samples from the urban Entebbe Mother and Baby Study (EMaBS), the rural General Population Cohort (GPC), the fishing community Lake Victoria Island Intervention Study on Worms and Allergy related Diseases (LaVIISWA) and the high-risk sexual behaviour Good Health for Women Project (GHWP), were tested for IgG antibody levels to K8.1 and ORF73 recombinant proteins using ELISA. All adult participants of the EMaBS study and the GHWP were women, while the GPC (54% female) and LaVIISWA (52% female) studies had both males and females. EMaBS children were all 5 years of age while their mothers were 14 to 47 years of age. GHWP women were 15 to 45 years old, LaVIISWA participants were 1 to 72 years old while GPC participants were 1 to 103 years old. KSHV seropositivity varied in the different populations. In children aged 5 years, EMaBS had the lowest prevalence of 15% followed by GPC at 35% and LaVIISWA at 54%. In adult women, seropositivity varied from 69% (EMaBS) to 80% (LaVIISWA) to 87% (GPC) to 90% (GHWP). The reasons for the variation in prevalence are unclear but may reflect differences in the prevalence of cofactors between these four geographically proximate populations.
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spelling pubmed-73766332020-07-23 Variation in KSHV prevalence between geographically proximate locations in Uganda Nalwoga, Angela Webb, Emily L. Muserere, Claudios Chihota, Belinda Miley, Wendell Labo, Nazzarena Elliott, Alison Cose, Stephen Whitby, Denise Newton, Robert Infect Agent Cancer Short Report Kaposi’s sarcoma-associated herpesvirus (KSHV) transmission within endemic areas may vary. KSHV seroprevalence has been studied by different groups of researchers using different methods, making it difficult to make direct comparisons. Here we show results on KSHV seroprevalence using the same laboratory method from four different but geographically proximate populations in Uganda. Blood samples from the urban Entebbe Mother and Baby Study (EMaBS), the rural General Population Cohort (GPC), the fishing community Lake Victoria Island Intervention Study on Worms and Allergy related Diseases (LaVIISWA) and the high-risk sexual behaviour Good Health for Women Project (GHWP), were tested for IgG antibody levels to K8.1 and ORF73 recombinant proteins using ELISA. All adult participants of the EMaBS study and the GHWP were women, while the GPC (54% female) and LaVIISWA (52% female) studies had both males and females. EMaBS children were all 5 years of age while their mothers were 14 to 47 years of age. GHWP women were 15 to 45 years old, LaVIISWA participants were 1 to 72 years old while GPC participants were 1 to 103 years old. KSHV seropositivity varied in the different populations. In children aged 5 years, EMaBS had the lowest prevalence of 15% followed by GPC at 35% and LaVIISWA at 54%. In adult women, seropositivity varied from 69% (EMaBS) to 80% (LaVIISWA) to 87% (GPC) to 90% (GHWP). The reasons for the variation in prevalence are unclear but may reflect differences in the prevalence of cofactors between these four geographically proximate populations. BioMed Central 2020-07-23 /pmc/articles/PMC7376633/ /pubmed/32714434 http://dx.doi.org/10.1186/s13027-020-00313-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Short Report
Nalwoga, Angela
Webb, Emily L.
Muserere, Claudios
Chihota, Belinda
Miley, Wendell
Labo, Nazzarena
Elliott, Alison
Cose, Stephen
Whitby, Denise
Newton, Robert
Variation in KSHV prevalence between geographically proximate locations in Uganda
title Variation in KSHV prevalence between geographically proximate locations in Uganda
title_full Variation in KSHV prevalence between geographically proximate locations in Uganda
title_fullStr Variation in KSHV prevalence between geographically proximate locations in Uganda
title_full_unstemmed Variation in KSHV prevalence between geographically proximate locations in Uganda
title_short Variation in KSHV prevalence between geographically proximate locations in Uganda
title_sort variation in kshv prevalence between geographically proximate locations in uganda
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376633/
https://www.ncbi.nlm.nih.gov/pubmed/32714434
http://dx.doi.org/10.1186/s13027-020-00313-8
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