Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma
Background: For lack of accurate early diagnosis and prognostic assessment, hepatocellular carcinoma (HCC) becomes severe challenge with the fourth cancer-related mortality. Recently, non-coding RNA (ncRNA) was identified to make functions in progression of various tumors. Among that, a novel ncRNA,...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376641/ https://www.ncbi.nlm.nih.gov/pubmed/32697317 http://dx.doi.org/10.1042/BSR20201479 |
_version_ | 1783562076923363328 |
---|---|
author | Ding, Yuan Sun, Zhongquan Zhang, Sitong Xu, Qianhui Zhou, Liuzhi Zhou, Dongkai Li, Yanjie Han, Xin Xu, Hao Bai, Yang Xu, Chang Ding, Hao Ge, Yao Wang, Weilin |
author_facet | Ding, Yuan Sun, Zhongquan Zhang, Sitong Xu, Qianhui Zhou, Liuzhi Zhou, Dongkai Li, Yanjie Han, Xin Xu, Hao Bai, Yang Xu, Chang Ding, Hao Ge, Yao Wang, Weilin |
author_sort | Ding, Yuan |
collection | PubMed |
description | Background: For lack of accurate early diagnosis and prognostic assessment, hepatocellular carcinoma (HCC) becomes severe challenge with the fourth cancer-related mortality. Recently, non-coding RNA (ncRNA) was identified to make functions in progression of various tumors. Among that, a novel ncRNA, small nucleolar RNA C/D box 31 (SNORD31) was suggested in previous study to function as potential tumor suppressing role. In the present study, we aimed to investigate the expression patterns and clinical significance of SNORD31 in HCC. Methods: SNORD31 expression was calculated in HCC cell lines as well as clinical specimens by RT-PCR. HCC patients were subdivided into high and low SNORD31 expression groups and their clinical characteristics were compared. Besides, the association between SNORD31 expression and postoperative prognosis was evaluated using Kaplan–Meier and Cox regression analysis. Results: Compared with corresponding normal reference, expression levels of SNORD31 were significantly down-regulated in both HCC cell lines and clinical specimens (P<0.01). Moreover, low SNORD31 expression was remarkably correlated with large tumor diameter, high incidence of vessel carcinoma embolus and capsular invasion, severe tumor differentiation and tumor-node-metastasis (TNM) stage (P<0.05). In the following analysis, HCC patients with low SNORD31 expression were independently inclined with poor tumor-free (median time: 9.17 vs 48.8 months, low vs high, P<0.001) as well as long-term survival (LTS; median time: 40.26 vs 55.41 months, low vs high, P=0.002). Conclusions: The ncRNA SNORD31 was proved to be commonly down-regulated in HCC and was independently associated with multiple malignant characteristics and long-term prognosis of HCC patients, which implied that SNORD31 possessed potential as a novel HCC biomarker. |
format | Online Article Text |
id | pubmed-7376641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73766412020-07-27 Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma Ding, Yuan Sun, Zhongquan Zhang, Sitong Xu, Qianhui Zhou, Liuzhi Zhou, Dongkai Li, Yanjie Han, Xin Xu, Hao Bai, Yang Xu, Chang Ding, Hao Ge, Yao Wang, Weilin Biosci Rep Cancer Background: For lack of accurate early diagnosis and prognostic assessment, hepatocellular carcinoma (HCC) becomes severe challenge with the fourth cancer-related mortality. Recently, non-coding RNA (ncRNA) was identified to make functions in progression of various tumors. Among that, a novel ncRNA, small nucleolar RNA C/D box 31 (SNORD31) was suggested in previous study to function as potential tumor suppressing role. In the present study, we aimed to investigate the expression patterns and clinical significance of SNORD31 in HCC. Methods: SNORD31 expression was calculated in HCC cell lines as well as clinical specimens by RT-PCR. HCC patients were subdivided into high and low SNORD31 expression groups and their clinical characteristics were compared. Besides, the association between SNORD31 expression and postoperative prognosis was evaluated using Kaplan–Meier and Cox regression analysis. Results: Compared with corresponding normal reference, expression levels of SNORD31 were significantly down-regulated in both HCC cell lines and clinical specimens (P<0.01). Moreover, low SNORD31 expression was remarkably correlated with large tumor diameter, high incidence of vessel carcinoma embolus and capsular invasion, severe tumor differentiation and tumor-node-metastasis (TNM) stage (P<0.05). In the following analysis, HCC patients with low SNORD31 expression were independently inclined with poor tumor-free (median time: 9.17 vs 48.8 months, low vs high, P<0.001) as well as long-term survival (LTS; median time: 40.26 vs 55.41 months, low vs high, P=0.002). Conclusions: The ncRNA SNORD31 was proved to be commonly down-regulated in HCC and was independently associated with multiple malignant characteristics and long-term prognosis of HCC patients, which implied that SNORD31 possessed potential as a novel HCC biomarker. Portland Press Ltd. 2020-07-22 /pmc/articles/PMC7376641/ /pubmed/32697317 http://dx.doi.org/10.1042/BSR20201479 Text en © 2020 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). |
spellingShingle | Cancer Ding, Yuan Sun, Zhongquan Zhang, Sitong Xu, Qianhui Zhou, Liuzhi Zhou, Dongkai Li, Yanjie Han, Xin Xu, Hao Bai, Yang Xu, Chang Ding, Hao Ge, Yao Wang, Weilin Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma |
title | Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma |
title_full | Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma |
title_fullStr | Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma |
title_full_unstemmed | Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma |
title_short | Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma |
title_sort | revealing the clinical significance and prognostic value of small nucleolar rna snord31 in hepatocellular carcinoma |
topic | Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376641/ https://www.ncbi.nlm.nih.gov/pubmed/32697317 http://dx.doi.org/10.1042/BSR20201479 |
work_keys_str_mv | AT dingyuan revealingtheclinicalsignificanceandprognosticvalueofsmallnucleolarrnasnord31inhepatocellularcarcinoma AT sunzhongquan revealingtheclinicalsignificanceandprognosticvalueofsmallnucleolarrnasnord31inhepatocellularcarcinoma AT zhangsitong revealingtheclinicalsignificanceandprognosticvalueofsmallnucleolarrnasnord31inhepatocellularcarcinoma AT xuqianhui revealingtheclinicalsignificanceandprognosticvalueofsmallnucleolarrnasnord31inhepatocellularcarcinoma AT zhouliuzhi revealingtheclinicalsignificanceandprognosticvalueofsmallnucleolarrnasnord31inhepatocellularcarcinoma AT zhoudongkai revealingtheclinicalsignificanceandprognosticvalueofsmallnucleolarrnasnord31inhepatocellularcarcinoma AT liyanjie revealingtheclinicalsignificanceandprognosticvalueofsmallnucleolarrnasnord31inhepatocellularcarcinoma AT hanxin revealingtheclinicalsignificanceandprognosticvalueofsmallnucleolarrnasnord31inhepatocellularcarcinoma AT xuhao revealingtheclinicalsignificanceandprognosticvalueofsmallnucleolarrnasnord31inhepatocellularcarcinoma AT baiyang revealingtheclinicalsignificanceandprognosticvalueofsmallnucleolarrnasnord31inhepatocellularcarcinoma AT xuchang revealingtheclinicalsignificanceandprognosticvalueofsmallnucleolarrnasnord31inhepatocellularcarcinoma AT dinghao revealingtheclinicalsignificanceandprognosticvalueofsmallnucleolarrnasnord31inhepatocellularcarcinoma AT geyao revealingtheclinicalsignificanceandprognosticvalueofsmallnucleolarrnasnord31inhepatocellularcarcinoma AT wangweilin revealingtheclinicalsignificanceandprognosticvalueofsmallnucleolarrnasnord31inhepatocellularcarcinoma |