Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma

Background: For lack of accurate early diagnosis and prognostic assessment, hepatocellular carcinoma (HCC) becomes severe challenge with the fourth cancer-related mortality. Recently, non-coding RNA (ncRNA) was identified to make functions in progression of various tumors. Among that, a novel ncRNA,...

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Autores principales: Ding, Yuan, Sun, Zhongquan, Zhang, Sitong, Xu, Qianhui, Zhou, Liuzhi, Zhou, Dongkai, Li, Yanjie, Han, Xin, Xu, Hao, Bai, Yang, Xu, Chang, Ding, Hao, Ge, Yao, Wang, Weilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376641/
https://www.ncbi.nlm.nih.gov/pubmed/32697317
http://dx.doi.org/10.1042/BSR20201479
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author Ding, Yuan
Sun, Zhongquan
Zhang, Sitong
Xu, Qianhui
Zhou, Liuzhi
Zhou, Dongkai
Li, Yanjie
Han, Xin
Xu, Hao
Bai, Yang
Xu, Chang
Ding, Hao
Ge, Yao
Wang, Weilin
author_facet Ding, Yuan
Sun, Zhongquan
Zhang, Sitong
Xu, Qianhui
Zhou, Liuzhi
Zhou, Dongkai
Li, Yanjie
Han, Xin
Xu, Hao
Bai, Yang
Xu, Chang
Ding, Hao
Ge, Yao
Wang, Weilin
author_sort Ding, Yuan
collection PubMed
description Background: For lack of accurate early diagnosis and prognostic assessment, hepatocellular carcinoma (HCC) becomes severe challenge with the fourth cancer-related mortality. Recently, non-coding RNA (ncRNA) was identified to make functions in progression of various tumors. Among that, a novel ncRNA, small nucleolar RNA C/D box 31 (SNORD31) was suggested in previous study to function as potential tumor suppressing role. In the present study, we aimed to investigate the expression patterns and clinical significance of SNORD31 in HCC. Methods: SNORD31 expression was calculated in HCC cell lines as well as clinical specimens by RT-PCR. HCC patients were subdivided into high and low SNORD31 expression groups and their clinical characteristics were compared. Besides, the association between SNORD31 expression and postoperative prognosis was evaluated using Kaplan–Meier and Cox regression analysis. Results: Compared with corresponding normal reference, expression levels of SNORD31 were significantly down-regulated in both HCC cell lines and clinical specimens (P<0.01). Moreover, low SNORD31 expression was remarkably correlated with large tumor diameter, high incidence of vessel carcinoma embolus and capsular invasion, severe tumor differentiation and tumor-node-metastasis (TNM) stage (P<0.05). In the following analysis, HCC patients with low SNORD31 expression were independently inclined with poor tumor-free (median time: 9.17 vs 48.8 months, low vs high, P<0.001) as well as long-term survival (LTS; median time: 40.26 vs 55.41 months, low vs high, P=0.002). Conclusions: The ncRNA SNORD31 was proved to be commonly down-regulated in HCC and was independently associated with multiple malignant characteristics and long-term prognosis of HCC patients, which implied that SNORD31 possessed potential as a novel HCC biomarker.
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spelling pubmed-73766412020-07-27 Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma Ding, Yuan Sun, Zhongquan Zhang, Sitong Xu, Qianhui Zhou, Liuzhi Zhou, Dongkai Li, Yanjie Han, Xin Xu, Hao Bai, Yang Xu, Chang Ding, Hao Ge, Yao Wang, Weilin Biosci Rep Cancer Background: For lack of accurate early diagnosis and prognostic assessment, hepatocellular carcinoma (HCC) becomes severe challenge with the fourth cancer-related mortality. Recently, non-coding RNA (ncRNA) was identified to make functions in progression of various tumors. Among that, a novel ncRNA, small nucleolar RNA C/D box 31 (SNORD31) was suggested in previous study to function as potential tumor suppressing role. In the present study, we aimed to investigate the expression patterns and clinical significance of SNORD31 in HCC. Methods: SNORD31 expression was calculated in HCC cell lines as well as clinical specimens by RT-PCR. HCC patients were subdivided into high and low SNORD31 expression groups and their clinical characteristics were compared. Besides, the association between SNORD31 expression and postoperative prognosis was evaluated using Kaplan–Meier and Cox regression analysis. Results: Compared with corresponding normal reference, expression levels of SNORD31 were significantly down-regulated in both HCC cell lines and clinical specimens (P<0.01). Moreover, low SNORD31 expression was remarkably correlated with large tumor diameter, high incidence of vessel carcinoma embolus and capsular invasion, severe tumor differentiation and tumor-node-metastasis (TNM) stage (P<0.05). In the following analysis, HCC patients with low SNORD31 expression were independently inclined with poor tumor-free (median time: 9.17 vs 48.8 months, low vs high, P<0.001) as well as long-term survival (LTS; median time: 40.26 vs 55.41 months, low vs high, P=0.002). Conclusions: The ncRNA SNORD31 was proved to be commonly down-regulated in HCC and was independently associated with multiple malignant characteristics and long-term prognosis of HCC patients, which implied that SNORD31 possessed potential as a novel HCC biomarker. Portland Press Ltd. 2020-07-22 /pmc/articles/PMC7376641/ /pubmed/32697317 http://dx.doi.org/10.1042/BSR20201479 Text en © 2020 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
spellingShingle Cancer
Ding, Yuan
Sun, Zhongquan
Zhang, Sitong
Xu, Qianhui
Zhou, Liuzhi
Zhou, Dongkai
Li, Yanjie
Han, Xin
Xu, Hao
Bai, Yang
Xu, Chang
Ding, Hao
Ge, Yao
Wang, Weilin
Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma
title Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma
title_full Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma
title_fullStr Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma
title_full_unstemmed Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma
title_short Revealing the clinical significance and prognostic value of small nucleolar RNA SNORD31 in hepatocellular carcinoma
title_sort revealing the clinical significance and prognostic value of small nucleolar rna snord31 in hepatocellular carcinoma
topic Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376641/
https://www.ncbi.nlm.nih.gov/pubmed/32697317
http://dx.doi.org/10.1042/BSR20201479
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