The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers

OBJECTIVE: Cytoreduction has an important role in improving the survival rate of epithelial ovarian cancer (EOC) patients. This study aimed to assess the ability of preoperative serum CA125, FASN and GLS as predictors of cytoreductive surgery for epithelial ovarian cancer (EOC). RESULTS: The average...

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Autores principales: Winarno, G. N. A., Hidayat, Y. M., Soetopo, S., Krisnadi, S. R., Tobing, M. D. L., Rauf, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376706/
https://www.ncbi.nlm.nih.gov/pubmed/32698888
http://dx.doi.org/10.1186/s13104-020-05188-x
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author Winarno, G. N. A.
Hidayat, Y. M.
Soetopo, S.
Krisnadi, S. R.
Tobing, M. D. L.
Rauf, S.
author_facet Winarno, G. N. A.
Hidayat, Y. M.
Soetopo, S.
Krisnadi, S. R.
Tobing, M. D. L.
Rauf, S.
author_sort Winarno, G. N. A.
collection PubMed
description OBJECTIVE: Cytoreduction has an important role in improving the survival rate of epithelial ovarian cancer (EOC) patients. This study aimed to assess the ability of preoperative serum CA125, FASN and GLS as predictors of cytoreductive surgery for epithelial ovarian cancer (EOC). RESULTS: The average values of serum CA-125, FASN, and GLS in the suboptimal cytoreduction group were higher than those in optimal cytoreduction group. The cut off point (COP) was 248.55 (p = 0.0001) with 73.2% sensitivity and 73.6% specificity for CA-125, 0.445 (p = 0.017) with 62.5% sensitivity and 60.4% specificity for FASN, and 22.895 (p = 0.0001) with 73.2% sensitivity and 75.5% specificity for GLS. The COP of CA-125 and GLS combined was 29.16 (p = 0.0001) with sensitivity 82.1% and specificity 73.6%, while the COP of CA-125, GLS, and FASN combined was 0.83 (p = 0.0001) with 87.5% sensitivity and 73.6% specificity.
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spelling pubmed-73767062020-07-23 The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers Winarno, G. N. A. Hidayat, Y. M. Soetopo, S. Krisnadi, S. R. Tobing, M. D. L. Rauf, S. BMC Res Notes Research Note OBJECTIVE: Cytoreduction has an important role in improving the survival rate of epithelial ovarian cancer (EOC) patients. This study aimed to assess the ability of preoperative serum CA125, FASN and GLS as predictors of cytoreductive surgery for epithelial ovarian cancer (EOC). RESULTS: The average values of serum CA-125, FASN, and GLS in the suboptimal cytoreduction group were higher than those in optimal cytoreduction group. The cut off point (COP) was 248.55 (p = 0.0001) with 73.2% sensitivity and 73.6% specificity for CA-125, 0.445 (p = 0.017) with 62.5% sensitivity and 60.4% specificity for FASN, and 22.895 (p = 0.0001) with 73.2% sensitivity and 75.5% specificity for GLS. The COP of CA-125 and GLS combined was 29.16 (p = 0.0001) with sensitivity 82.1% and specificity 73.6%, while the COP of CA-125, GLS, and FASN combined was 0.83 (p = 0.0001) with 87.5% sensitivity and 73.6% specificity. BioMed Central 2020-07-22 /pmc/articles/PMC7376706/ /pubmed/32698888 http://dx.doi.org/10.1186/s13104-020-05188-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Winarno, G. N. A.
Hidayat, Y. M.
Soetopo, S.
Krisnadi, S. R.
Tobing, M. D. L.
Rauf, S.
The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers
title The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers
title_full The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers
title_fullStr The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers
title_full_unstemmed The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers
title_short The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers
title_sort role of ca-125, gls and fasn in predicting cytoreduction for epithelial ovarian cancers
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376706/
https://www.ncbi.nlm.nih.gov/pubmed/32698888
http://dx.doi.org/10.1186/s13104-020-05188-x
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