Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis

HSV-1 encephalitis (HSE) is typically sporadic. Inborn errors of TLR3- and DBR1-mediated central nervous system (CNS) cell-intrinsic immunity can account for forebrain and brainstem HSE, respectively. We report five unrelated patients with forebrain HSE, each heterozygous for one of four rare varian...

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Detalles Bibliográficos
Autores principales: Lafaille, Fabien G., Harschnitz, Oliver, Lee, Yoon Seung, Zhang, Peng, Hasek, Mary L., Kerner, Gaspard, Itan, Yuval, Ewaleifoh, Osefame, Rapaport, Franck, Carlile, Thomas M., Carter-Timofte, Madalina E., Paquet, Dominik, Dobbs, Kerry, Zimmer, Bastian, Gao, Daxing, Rojas-Duran, Maria F., Kwart, Dylan, Rattina, Vimel, Ciancanelli, Michael J., McAlpine, Jessica L., Lorenzo, Lazaro, Boucherit, Soraya, Rozenberg, Flore, Halwani, Rabih, Henry, Benoit, Amenzoui, Naima, Alsum, Zobaida, Marques, Laura, Church, Joseph A., Al-Muhsen, Saleh, Tardieu, Marc, Bousfiha, Ahmed Aziz, Paludan, Søren R., Mogensen, Trine Hyrup, Quintana-Murci, Lluis, Tessier-Lavigne, Marc, Smith, Gregory A., Notarangelo, Luigi D., Studer, Lorenz, Gilbert, Wendy, Abel, Laurent, Casanova, Jean-Laurent, Zhang, Shen-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376819/
https://www.ncbi.nlm.nih.gov/pubmed/31806906
http://dx.doi.org/10.1038/s41591-019-0672-3

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