Advances in understanding of angioimmunoblastic T-cell lymphoma

It has been nearly half a century since angioimmunoblastic T-cell lymphoma (AITL) was characterized in the early 1970’s. Our understanding of the disease has dramatically changed due to multiple discoveries and insights. One of the key features of AITL is aberrant immune activity. Although AITL is n...

Descripción completa

Detalles Bibliográficos
Autores principales: Chiba, Shigeru, Sakata-Yanagimoto, Mamiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376827/
https://www.ncbi.nlm.nih.gov/pubmed/32704161
http://dx.doi.org/10.1038/s41375-020-0990-y
_version_ 1783562106897956864
author Chiba, Shigeru
Sakata-Yanagimoto, Mamiko
author_facet Chiba, Shigeru
Sakata-Yanagimoto, Mamiko
author_sort Chiba, Shigeru
collection PubMed
description It has been nearly half a century since angioimmunoblastic T-cell lymphoma (AITL) was characterized in the early 1970’s. Our understanding of the disease has dramatically changed due to multiple discoveries and insights. One of the key features of AITL is aberrant immune activity. Although AITL is now understood to be a neoplastic disease, pathologists appreciated that it was an inflammatory condition. The more we understand AITL at cellular and genetic levels, the more we view it as both a neoplastic and an inflammatory disease. Here, we review recent progress in our understanding of AITL, focusing on as yet unsolved questions.
format Online
Article
Text
id pubmed-7376827
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-73768272020-07-23 Advances in understanding of angioimmunoblastic T-cell lymphoma Chiba, Shigeru Sakata-Yanagimoto, Mamiko Leukemia Review Article It has been nearly half a century since angioimmunoblastic T-cell lymphoma (AITL) was characterized in the early 1970’s. Our understanding of the disease has dramatically changed due to multiple discoveries and insights. One of the key features of AITL is aberrant immune activity. Although AITL is now understood to be a neoplastic disease, pathologists appreciated that it was an inflammatory condition. The more we understand AITL at cellular and genetic levels, the more we view it as both a neoplastic and an inflammatory disease. Here, we review recent progress in our understanding of AITL, focusing on as yet unsolved questions. Nature Publishing Group UK 2020-07-23 2020 /pmc/articles/PMC7376827/ /pubmed/32704161 http://dx.doi.org/10.1038/s41375-020-0990-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Chiba, Shigeru
Sakata-Yanagimoto, Mamiko
Advances in understanding of angioimmunoblastic T-cell lymphoma
title Advances in understanding of angioimmunoblastic T-cell lymphoma
title_full Advances in understanding of angioimmunoblastic T-cell lymphoma
title_fullStr Advances in understanding of angioimmunoblastic T-cell lymphoma
title_full_unstemmed Advances in understanding of angioimmunoblastic T-cell lymphoma
title_short Advances in understanding of angioimmunoblastic T-cell lymphoma
title_sort advances in understanding of angioimmunoblastic t-cell lymphoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376827/
https://www.ncbi.nlm.nih.gov/pubmed/32704161
http://dx.doi.org/10.1038/s41375-020-0990-y
work_keys_str_mv AT chibashigeru advancesinunderstandingofangioimmunoblastictcelllymphoma
AT sakatayanagimotomamiko advancesinunderstandingofangioimmunoblastictcelllymphoma

Ejemplares similares