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Risk of chronic kidney disease in patients with kidney stones—a nationwide cohort study

BACKGROUND: Chronic kidney disease (CKD) and kidney stones are common in Taiwan; in particular, CKD has a high prevalence but low self-awareness rate. CKD-related risk factors such as diabetes, hypertension, and nephrotoxic drugs are well-known and uncontested; however, kidney stones are relatively...

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Autores principales: Chuang, Tzung-Fang, Hung, Hung-Chang, Li, Shu-Fen, Lee, Mei-Wen, Pai, Jar-Yuan, Hung, Chin-Tun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376912/
https://www.ncbi.nlm.nih.gov/pubmed/32698782
http://dx.doi.org/10.1186/s12882-020-01950-2
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author Chuang, Tzung-Fang
Hung, Hung-Chang
Li, Shu-Fen
Lee, Mei-Wen
Pai, Jar-Yuan
Hung, Chin-Tun
author_facet Chuang, Tzung-Fang
Hung, Hung-Chang
Li, Shu-Fen
Lee, Mei-Wen
Pai, Jar-Yuan
Hung, Chin-Tun
author_sort Chuang, Tzung-Fang
collection PubMed
description BACKGROUND: Chronic kidney disease (CKD) and kidney stones are common in Taiwan; in particular, CKD has a high prevalence but low self-awareness rate. CKD-related risk factors such as diabetes, hypertension, and nephrotoxic drugs are well-known and uncontested; however, kidney stones are relatively less studied and easily overlooked as a risk factor. The objective of this study was to investigate whether kidney stones are a risk factor for CKD. METHODS: We conducted a nationwide population-based matched cohort study to assess the risk of incident CKD in people with kidney stones. Data on incident stones formers in the year 2001—excluding those with a history of CKD—were obtained from Taiwan’s National Health Insurance database. Stone formers were matched (1:4) to control subjects according to sex, age, and index date. The total observation period of the study was 10 years, and the primary end-point was the occurrence of CKD. Student’s t-test and Chi-squared test were used to compare continuous and categorical data, respectively. Logistic regression was used to calculate the odds ratio of kidney stone patients with incident CKD relative to the control group. Cox proportional hazard regression model was used to obtain the hazard ratio for development of incident CKD among patients with kidney stones. RESULTS: The incidence of CKD in the kidney stone cohort was 11.2%, which was significantly higher than that of the control group (P < .001). Survival analysis showed that the stones cohort was 1.82 times more likely to experience CKD than the controls. Age, sex, hypertension, diabetes mellitus, and hyperlipidemia increased the risk of CKD incidence (1.04, 1.27, 1.55, 3.31, and 1.25 times, respectively). CONCLUSION: Kidney stones are a definite risk factor for CKD; therefore, patients with stones are suggested to undergo regular renal function monitoring and receive appropriate treatment to avoid CKD.
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spelling pubmed-73769122020-08-04 Risk of chronic kidney disease in patients with kidney stones—a nationwide cohort study Chuang, Tzung-Fang Hung, Hung-Chang Li, Shu-Fen Lee, Mei-Wen Pai, Jar-Yuan Hung, Chin-Tun BMC Nephrol Research Article BACKGROUND: Chronic kidney disease (CKD) and kidney stones are common in Taiwan; in particular, CKD has a high prevalence but low self-awareness rate. CKD-related risk factors such as diabetes, hypertension, and nephrotoxic drugs are well-known and uncontested; however, kidney stones are relatively less studied and easily overlooked as a risk factor. The objective of this study was to investigate whether kidney stones are a risk factor for CKD. METHODS: We conducted a nationwide population-based matched cohort study to assess the risk of incident CKD in people with kidney stones. Data on incident stones formers in the year 2001—excluding those with a history of CKD—were obtained from Taiwan’s National Health Insurance database. Stone formers were matched (1:4) to control subjects according to sex, age, and index date. The total observation period of the study was 10 years, and the primary end-point was the occurrence of CKD. Student’s t-test and Chi-squared test were used to compare continuous and categorical data, respectively. Logistic regression was used to calculate the odds ratio of kidney stone patients with incident CKD relative to the control group. Cox proportional hazard regression model was used to obtain the hazard ratio for development of incident CKD among patients with kidney stones. RESULTS: The incidence of CKD in the kidney stone cohort was 11.2%, which was significantly higher than that of the control group (P < .001). Survival analysis showed that the stones cohort was 1.82 times more likely to experience CKD than the controls. Age, sex, hypertension, diabetes mellitus, and hyperlipidemia increased the risk of CKD incidence (1.04, 1.27, 1.55, 3.31, and 1.25 times, respectively). CONCLUSION: Kidney stones are a definite risk factor for CKD; therefore, patients with stones are suggested to undergo regular renal function monitoring and receive appropriate treatment to avoid CKD. BioMed Central 2020-07-22 /pmc/articles/PMC7376912/ /pubmed/32698782 http://dx.doi.org/10.1186/s12882-020-01950-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Chuang, Tzung-Fang
Hung, Hung-Chang
Li, Shu-Fen
Lee, Mei-Wen
Pai, Jar-Yuan
Hung, Chin-Tun
Risk of chronic kidney disease in patients with kidney stones—a nationwide cohort study
title Risk of chronic kidney disease in patients with kidney stones—a nationwide cohort study
title_full Risk of chronic kidney disease in patients with kidney stones—a nationwide cohort study
title_fullStr Risk of chronic kidney disease in patients with kidney stones—a nationwide cohort study
title_full_unstemmed Risk of chronic kidney disease in patients with kidney stones—a nationwide cohort study
title_short Risk of chronic kidney disease in patients with kidney stones—a nationwide cohort study
title_sort risk of chronic kidney disease in patients with kidney stones—a nationwide cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376912/
https://www.ncbi.nlm.nih.gov/pubmed/32698782
http://dx.doi.org/10.1186/s12882-020-01950-2
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