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Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang

BACKGROUND: Some studies have shown that a high level of bilirubin is a protective factor against metabolic syndrome (MS), while a high level of transaminase is a risk factor for MS. However, the existing results are inconsistent and few cohort studies have been published. METHODS: Using an ambispec...

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Autores principales: Hao, Hao, Guo, Heng, Ma, Ru-lin, Yan, Yi-zhong, Hu, Yun-hua, Ma, Jiao-long, Zhang, Xiang-hui, Wang, Xin-ping, Wang, Kui, Mu, La-ti, Song, Yan-peng, Zhang, Jing-yu, He, Jia, Guo, Shu-xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376964/
https://www.ncbi.nlm.nih.gov/pubmed/32698889
http://dx.doi.org/10.1186/s12902-020-00563-y
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author Hao, Hao
Guo, Heng
Ma, Ru-lin
Yan, Yi-zhong
Hu, Yun-hua
Ma, Jiao-long
Zhang, Xiang-hui
Wang, Xin-ping
Wang, Kui
Mu, La-ti
Song, Yan-peng
Zhang, Jing-yu
He, Jia
Guo, Shu-xia
author_facet Hao, Hao
Guo, Heng
Ma, Ru-lin
Yan, Yi-zhong
Hu, Yun-hua
Ma, Jiao-long
Zhang, Xiang-hui
Wang, Xin-ping
Wang, Kui
Mu, La-ti
Song, Yan-peng
Zhang, Jing-yu
He, Jia
Guo, Shu-xia
author_sort Hao, Hao
collection PubMed
description BACKGROUND: Some studies have shown that a high level of bilirubin is a protective factor against metabolic syndrome (MS), while a high level of transaminase is a risk factor for MS. However, the existing results are inconsistent and few cohort studies have been published. METHODS: Using an ambispective cohort study, 565 Kazakhs from Xinjiang, China were selected as the study subjects. The baseline serum bilirubin and transaminase levels of the subjects were divided into quartiles and the relationship between these values and the incidence of MS was analyzed. The definition of MS was based on the Joint Interim Statement (JIS) diagnostic criteria. RESULTS: The average follow-up time for the subjects was 5.72 years. The cumulative incidence of MS was 36.11% (204 of the 565 subjects), and the incidence density was 63.10/1000 person-years. Multivariate Cox regression analysis showed that the levels of total bilirubin (TBIL) and indirect bilirubin (IBIL) were negatively correlated with the occurrence of MS, Compared to the lowest quartile level (Q1), the hazard ratios of MS the TBIL levels at the Q2-Q4 quartiles were: 0.47 (0.31–0.71), 0.53 (0.35–0.79), and 0.48 (0.32–0.72), respectively, while IBIL levels at the Q2-Q4 quartiles showed an MS hazard ratio of 0.48 (0.32–0.72), 0.54(0.36–0.81), and 0.52 (0.35–0.77), respectively, all at a 95% confidence level. However, no relationship was found between transaminase levels and the incidence of MS. CONCLUSION: Serum TBIL and IBIL levels were negatively correlated with the incidence of MS in a Kazakh population in China.
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spelling pubmed-73769642020-08-04 Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang Hao, Hao Guo, Heng Ma, Ru-lin Yan, Yi-zhong Hu, Yun-hua Ma, Jiao-long Zhang, Xiang-hui Wang, Xin-ping Wang, Kui Mu, La-ti Song, Yan-peng Zhang, Jing-yu He, Jia Guo, Shu-xia BMC Endocr Disord Research Article BACKGROUND: Some studies have shown that a high level of bilirubin is a protective factor against metabolic syndrome (MS), while a high level of transaminase is a risk factor for MS. However, the existing results are inconsistent and few cohort studies have been published. METHODS: Using an ambispective cohort study, 565 Kazakhs from Xinjiang, China were selected as the study subjects. The baseline serum bilirubin and transaminase levels of the subjects were divided into quartiles and the relationship between these values and the incidence of MS was analyzed. The definition of MS was based on the Joint Interim Statement (JIS) diagnostic criteria. RESULTS: The average follow-up time for the subjects was 5.72 years. The cumulative incidence of MS was 36.11% (204 of the 565 subjects), and the incidence density was 63.10/1000 person-years. Multivariate Cox regression analysis showed that the levels of total bilirubin (TBIL) and indirect bilirubin (IBIL) were negatively correlated with the occurrence of MS, Compared to the lowest quartile level (Q1), the hazard ratios of MS the TBIL levels at the Q2-Q4 quartiles were: 0.47 (0.31–0.71), 0.53 (0.35–0.79), and 0.48 (0.32–0.72), respectively, while IBIL levels at the Q2-Q4 quartiles showed an MS hazard ratio of 0.48 (0.32–0.72), 0.54(0.36–0.81), and 0.52 (0.35–0.77), respectively, all at a 95% confidence level. However, no relationship was found between transaminase levels and the incidence of MS. CONCLUSION: Serum TBIL and IBIL levels were negatively correlated with the incidence of MS in a Kazakh population in China. BioMed Central 2020-07-22 /pmc/articles/PMC7376964/ /pubmed/32698889 http://dx.doi.org/10.1186/s12902-020-00563-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Hao, Hao
Guo, Heng
Ma, Ru-lin
Yan, Yi-zhong
Hu, Yun-hua
Ma, Jiao-long
Zhang, Xiang-hui
Wang, Xin-ping
Wang, Kui
Mu, La-ti
Song, Yan-peng
Zhang, Jing-yu
He, Jia
Guo, Shu-xia
Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang
title Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang
title_full Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang
title_fullStr Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang
title_full_unstemmed Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang
title_short Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang
title_sort association of total bilirubin and indirect bilirubin content with metabolic syndrome among kazakhs in xinjiang
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376964/
https://www.ncbi.nlm.nih.gov/pubmed/32698889
http://dx.doi.org/10.1186/s12902-020-00563-y
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