Sex-Specific Intubation Biomechanics: Intubation Forces Are Greater in Male Than in Female Patients, Independent of Body Weight

Background Studies of head, neck, and cervical spine morphology and tissue material properties indicate that cervical spine biomechanics differ between adult males and females. These differences result in sex-specific cervical spine kinematics and injury patterns in response to standardized loading conditions. Because direct laryngoscopy and endotracheal intubation require the application of a load to the cervical spine, intubation biomechanics should be sex-specific. The aim of this study was to determine if intubation forces during direct laryngoscopy differ between male and female patients and, if so, is the difference independent of body weight. Methods We pooled original data from three previously published adult clinical intubation studies that used methodologically reliable intubation force measurements (measured total laryngoscope force applied to the tongue, and force values were insensitive to or accounted for other laryngoscope blade forces). All patients had undergone direct laryngoscopy and orotracheal intubation with a Macintosh 3 blade under general anesthesia. Patient data included sex, age, height, weight, and maximum intubation force. Least squares multivariable linear regression was performed between the dependent variable (maximum intubation force) and two independent variables (patient sex and patient weight). A third term was added for the interaction between patient sex and weight. Results Among all patients (males n=42, females n=59), the median intubation force was 42.2 N (25(th) to 75(th) percentiles: 31.5 to 57.4 N). While controlling for patient body weight, intubation force differed between the sexes; P=0.011, with greater intubation force in male patients. While controlling for patient sex, there was a positive association between patient body weight and intubation force; P=0.009. In addition, there was a significant interaction between patient sex and weight; P=0.002, with intubation force in male patients having greater dependence on body weight. The difference in intubation force between male and female patients who had the same body weight exceeded 5 N when body weight exceeded 75 kg, and intubation force differences between male and female patients increased as patient body weight increased. Additional analyses using robust regression and using body mass index instead of weight provided comparable results. Conclusion In adult patients, the biomechanics of direct laryngoscopy and intubation are sex-specific. Our findings support the need to control for patient sex and weight in future clinical and laboratory studies of the human cervical spine and head and neck biomechanics.