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Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells
Lung cancer is the most prevalent type of cancer worldwide and is the leading cause of cancer-associated cases of mortality in the USA and China. Non-small cell lung cancer (NSCLC) accounts for 80–85% of lung cancer cases. microRNAs (miRs) serve multiple roles in the pathogenesis of lung cancer. The...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377081/ https://www.ncbi.nlm.nih.gov/pubmed/32724366 http://dx.doi.org/10.3892/ol.2020.11649 |
Sumario: | Lung cancer is the most prevalent type of cancer worldwide and is the leading cause of cancer-associated cases of mortality in the USA and China. Non-small cell lung cancer (NSCLC) accounts for 80–85% of lung cancer cases. microRNAs (miRs) serve multiple roles in the pathogenesis of lung cancer. The current study investigated the lower level of miR-200a in tumor tissues compared with healthy tissue. Overexpression of miR-200a inhibited NSCLC cell proliferation and promoted apoptosis. miR-200a was identified to target Rhophilin Rho GTPase binding protein 2 (RHPN2) and higher levels of RHPN2 were observed in tumor tissues compared with adjacent normal tissues. The current study proposes that miR-200a exhibits a tumor suppressive role in NSCLC and suggests that miR-200a could target RHPN2. |
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