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Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells

Lung cancer is the most prevalent type of cancer worldwide and is the leading cause of cancer-associated cases of mortality in the USA and China. Non-small cell lung cancer (NSCLC) accounts for 80–85% of lung cancer cases. microRNAs (miRs) serve multiple roles in the pathogenesis of lung cancer. The...

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Detalles Bibliográficos
Autores principales: Huang, Yan, Bao, Ting, Li, Zhenzhen, Ji, Guiyi, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377081/
https://www.ncbi.nlm.nih.gov/pubmed/32724366
http://dx.doi.org/10.3892/ol.2020.11649
Descripción
Sumario:Lung cancer is the most prevalent type of cancer worldwide and is the leading cause of cancer-associated cases of mortality in the USA and China. Non-small cell lung cancer (NSCLC) accounts for 80–85% of lung cancer cases. microRNAs (miRs) serve multiple roles in the pathogenesis of lung cancer. The current study investigated the lower level of miR-200a in tumor tissues compared with healthy tissue. Overexpression of miR-200a inhibited NSCLC cell proliferation and promoted apoptosis. miR-200a was identified to target Rhophilin Rho GTPase binding protein 2 (RHPN2) and higher levels of RHPN2 were observed in tumor tissues compared with adjacent normal tissues. The current study proposes that miR-200a exhibits a tumor suppressive role in NSCLC and suggests that miR-200a could target RHPN2.