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Blood cell parameters as prognostic predictors of disease development for patients with advanced non-small cell lung cancer

Although the prognostic value of the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and lymphocyte/white blood cell ratio (LWR) has been described in advanced non-small cell lung cancer (NSCLC), the association between complete blood cell parameters prior to disease treatment and...

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Autores principales: Wang, Leirong, Si, Hongzong, Wang, Jing, Feng, Lingxin, Zhai, Wenxin, Dong, Shenghua, Yu, Zhuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377095/
https://www.ncbi.nlm.nih.gov/pubmed/32724349
http://dx.doi.org/10.3892/ol.2020.11655
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author Wang, Leirong
Si, Hongzong
Wang, Jing
Feng, Lingxin
Zhai, Wenxin
Dong, Shenghua
Yu, Zhuang
author_facet Wang, Leirong
Si, Hongzong
Wang, Jing
Feng, Lingxin
Zhai, Wenxin
Dong, Shenghua
Yu, Zhuang
author_sort Wang, Leirong
collection PubMed
description Although the prognostic value of the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and lymphocyte/white blood cell ratio (LWR) has been described in advanced non-small cell lung cancer (NSCLC), the association between complete blood cell parameters prior to disease treatment and NSCLC have yet to be identified. The aim of the present study was to assess the complete blood cell parameters prior to disease treatment in patients with advanced NSCLC. A total of 268 patients with advanced NSCLC were enrolled in this study. Clinical and laboratory data of the patients were acquired through medical records. Receiver operating characteristic curve analysis was used to determine the optimal cut-off values of the neutrophil/white blood cell ratio (NWR), NLR, platelet/white blood cell ratio (PWR), PLR, monocyte/white blood cell ratio (MWR), monocyte/lymphocyte ratio (MLR) and LWR. Kaplan-Meier univariate and multivariate Cox regression analyses were used to evaluate the effect of complete blood parameters on progression-free survival (PFS) and overall survival (OS). The optimal cut-off values were identified as 0.67 for NWR, 2.85 for NLR, 37.23 for PWR, 166.56 for PLR, 0.074 for MWR, 0.31 for MLR and 0.24 for LWR. Univariate analysis revealed that sex (P=0.038), histological type (P<0.0001), NWR (P=0.026), NLR (P=0.044) and MLR (P=0.012) were all associated with PFS, whereas histological type (P=0.003), NWR (P=0.003), NLR (P=0.015), MLR (P=0.006) and LWR (P=0.043) were significantly associated with OS in patients with advanced NSCLC. Histological type (P=0.002) was an independent prognostic factor for PFS in patients with advanced NSCLC. Whereas histological type (P=0.005), NWR (P=0.005), NLR (P=0.014), MLR (P=0.006), and LWR (P=0.034) were independent prognostic factors for OS. Taken together, the present study identified high NWR, NLR and MLR, and low LWR as independent prognostic factors for poor OS in patients with NSCLC.
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spelling pubmed-73770952020-07-27 Blood cell parameters as prognostic predictors of disease development for patients with advanced non-small cell lung cancer Wang, Leirong Si, Hongzong Wang, Jing Feng, Lingxin Zhai, Wenxin Dong, Shenghua Yu, Zhuang Oncol Lett Articles Although the prognostic value of the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and lymphocyte/white blood cell ratio (LWR) has been described in advanced non-small cell lung cancer (NSCLC), the association between complete blood cell parameters prior to disease treatment and NSCLC have yet to be identified. The aim of the present study was to assess the complete blood cell parameters prior to disease treatment in patients with advanced NSCLC. A total of 268 patients with advanced NSCLC were enrolled in this study. Clinical and laboratory data of the patients were acquired through medical records. Receiver operating characteristic curve analysis was used to determine the optimal cut-off values of the neutrophil/white blood cell ratio (NWR), NLR, platelet/white blood cell ratio (PWR), PLR, monocyte/white blood cell ratio (MWR), monocyte/lymphocyte ratio (MLR) and LWR. Kaplan-Meier univariate and multivariate Cox regression analyses were used to evaluate the effect of complete blood parameters on progression-free survival (PFS) and overall survival (OS). The optimal cut-off values were identified as 0.67 for NWR, 2.85 for NLR, 37.23 for PWR, 166.56 for PLR, 0.074 for MWR, 0.31 for MLR and 0.24 for LWR. Univariate analysis revealed that sex (P=0.038), histological type (P<0.0001), NWR (P=0.026), NLR (P=0.044) and MLR (P=0.012) were all associated with PFS, whereas histological type (P=0.003), NWR (P=0.003), NLR (P=0.015), MLR (P=0.006) and LWR (P=0.043) were significantly associated with OS in patients with advanced NSCLC. Histological type (P=0.002) was an independent prognostic factor for PFS in patients with advanced NSCLC. Whereas histological type (P=0.005), NWR (P=0.005), NLR (P=0.014), MLR (P=0.006), and LWR (P=0.034) were independent prognostic factors for OS. Taken together, the present study identified high NWR, NLR and MLR, and low LWR as independent prognostic factors for poor OS in patients with NSCLC. D.A. Spandidos 2020-08 2020-05-21 /pmc/articles/PMC7377095/ /pubmed/32724349 http://dx.doi.org/10.3892/ol.2020.11655 Text en Copyright: © Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Wang, Leirong
Si, Hongzong
Wang, Jing
Feng, Lingxin
Zhai, Wenxin
Dong, Shenghua
Yu, Zhuang
Blood cell parameters as prognostic predictors of disease development for patients with advanced non-small cell lung cancer
title Blood cell parameters as prognostic predictors of disease development for patients with advanced non-small cell lung cancer
title_full Blood cell parameters as prognostic predictors of disease development for patients with advanced non-small cell lung cancer
title_fullStr Blood cell parameters as prognostic predictors of disease development for patients with advanced non-small cell lung cancer
title_full_unstemmed Blood cell parameters as prognostic predictors of disease development for patients with advanced non-small cell lung cancer
title_short Blood cell parameters as prognostic predictors of disease development for patients with advanced non-small cell lung cancer
title_sort blood cell parameters as prognostic predictors of disease development for patients with advanced non-small cell lung cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377095/
https://www.ncbi.nlm.nih.gov/pubmed/32724349
http://dx.doi.org/10.3892/ol.2020.11655
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