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Successful Reduction of Neointimal Hyperplasia on Stainless Steel Coronary Stents by Titania Nanotexturing

[Image: see text] Bare metal stents (BMSs) of stainless steel (SS) were surface engineered to develop nanoscale titania topography using a combination of physical vapor deposition and thermochemical processing. The nanoleafy architecture formed on the stent surface remained stable and adherent upon...

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Autores principales: Cherian, Aleena Mary, Joseph, John, Nair, Manitha B., Nair, Shantikumar V., Maniyal, Vijayakumar, Menon, Deepthy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377224/
https://www.ncbi.nlm.nih.gov/pubmed/32715243
http://dx.doi.org/10.1021/acsomega.0c02045
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author Cherian, Aleena Mary
Joseph, John
Nair, Manitha B.
Nair, Shantikumar V.
Maniyal, Vijayakumar
Menon, Deepthy
author_facet Cherian, Aleena Mary
Joseph, John
Nair, Manitha B.
Nair, Shantikumar V.
Maniyal, Vijayakumar
Menon, Deepthy
author_sort Cherian, Aleena Mary
collection PubMed
description [Image: see text] Bare metal stents (BMSs) of stainless steel (SS) were surface engineered to develop nanoscale titania topography using a combination of physical vapor deposition and thermochemical processing. The nanoleafy architecture formed on the stent surface remained stable and adherent upon repeated crimping and expansion, as well as under flow. This titania nanoengineered stent showed a preferential proliferation of endothelial cells over smooth muscle cells in vitro, which is an essential requirement for improving the in vivo endothelialization, with concurrent reduction of intimal hyperplasia. The efficacy of this surface-modified stent was assessed after implantation in rabbit iliac arteries for 8 weeks. Significant reduction in neointimal thickening and thereby in-stent restenosis with complete endothelial coverage was observed for the nanotextured stents, compared to BMSs, even without the use of any antiproliferative agents or polymers as in drug-eluting stents. Nanotexturing of stents did not induce any inflammatory response, akin to BMSs. This study thus indicates the effectiveness of a facile titania nanotopography on SS stents for coronary applications and the possibility of bringing this low-priced material back to clinics.
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spelling pubmed-73772242020-07-24 Successful Reduction of Neointimal Hyperplasia on Stainless Steel Coronary Stents by Titania Nanotexturing Cherian, Aleena Mary Joseph, John Nair, Manitha B. Nair, Shantikumar V. Maniyal, Vijayakumar Menon, Deepthy ACS Omega [Image: see text] Bare metal stents (BMSs) of stainless steel (SS) were surface engineered to develop nanoscale titania topography using a combination of physical vapor deposition and thermochemical processing. The nanoleafy architecture formed on the stent surface remained stable and adherent upon repeated crimping and expansion, as well as under flow. This titania nanoengineered stent showed a preferential proliferation of endothelial cells over smooth muscle cells in vitro, which is an essential requirement for improving the in vivo endothelialization, with concurrent reduction of intimal hyperplasia. The efficacy of this surface-modified stent was assessed after implantation in rabbit iliac arteries for 8 weeks. Significant reduction in neointimal thickening and thereby in-stent restenosis with complete endothelial coverage was observed for the nanotextured stents, compared to BMSs, even without the use of any antiproliferative agents or polymers as in drug-eluting stents. Nanotexturing of stents did not induce any inflammatory response, akin to BMSs. This study thus indicates the effectiveness of a facile titania nanotopography on SS stents for coronary applications and the possibility of bringing this low-priced material back to clinics. American Chemical Society 2020-07-07 /pmc/articles/PMC7377224/ /pubmed/32715243 http://dx.doi.org/10.1021/acsomega.0c02045 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Cherian, Aleena Mary
Joseph, John
Nair, Manitha B.
Nair, Shantikumar V.
Maniyal, Vijayakumar
Menon, Deepthy
Successful Reduction of Neointimal Hyperplasia on Stainless Steel Coronary Stents by Titania Nanotexturing
title Successful Reduction of Neointimal Hyperplasia on Stainless Steel Coronary Stents by Titania Nanotexturing
title_full Successful Reduction of Neointimal Hyperplasia on Stainless Steel Coronary Stents by Titania Nanotexturing
title_fullStr Successful Reduction of Neointimal Hyperplasia on Stainless Steel Coronary Stents by Titania Nanotexturing
title_full_unstemmed Successful Reduction of Neointimal Hyperplasia on Stainless Steel Coronary Stents by Titania Nanotexturing
title_short Successful Reduction of Neointimal Hyperplasia on Stainless Steel Coronary Stents by Titania Nanotexturing
title_sort successful reduction of neointimal hyperplasia on stainless steel coronary stents by titania nanotexturing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377224/
https://www.ncbi.nlm.nih.gov/pubmed/32715243
http://dx.doi.org/10.1021/acsomega.0c02045
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