PTH Hypersecretion Triggered by a GABA(B1) and Ca(2+)-sensing Receptor Heterocomplex in Hyperparathyroidism

Molecular mechanisms mediating tonic secretion of parathyroid hormone (PTH) in response to hypocalcemia and hyperparathyroidism (HPT) are unclear. Here we demonstrate increased heterocomplex formation between the calcium-sensing receptor (CaSR) and metabotropic GABA(B1) receptor (GABA(B1)R) in hyper...

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Detalles Bibliográficos
Autores principales: Chang, Wenhan, Tu, Chia-Ling, Jean-Alphonse, Frederic, Herberger, Amanda, Cheng, Zhiqiang, Hwong, Jenna, Ho, Hanson, Li, Alfred, Wang, Dawei, Liu, Hongda, White, Alex D., Suh, Insoo, Shen, Wen, Duh, Quan-Yang, Khanafshar, Elham, Shoback, Dolores M., Xiao, Kunhong, Vilardaga, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377265/
https://www.ncbi.nlm.nih.gov/pubmed/32694772
http://dx.doi.org/10.1038/s42255-020-0175-z

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