Nuclear IGF1R interact with PCNA to preserve DNA replication after DNA-damage in a variety of human cancers

Nuclear IGF1R has been linked to poor outcome in cancer. We recently showed that nuclear IGF1R phosphorylates PCNA and increases DNA damage tolerance. In this paper we aimed to describe this mechanism in cancer tissue as well as in cancer cell lines. In situ proximity ligation assay identified frequ...

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Detalles Bibliográficos
Autores principales: Yang, Chen, Zhang, Yifan, Chen, Yi, Ragaller, Franziska, Liu, Mingzhi, Corvigno, Sara, Dahlstrand, Hanna, Carlson, Joseph, Chen, Zihua, Näsman, Anders, Waraky, Ahmed, Lin, Yingbo, Larsson, Olle, Haglund, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377393/
https://www.ncbi.nlm.nih.gov/pubmed/32701997
http://dx.doi.org/10.1371/journal.pone.0236291

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