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Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial

More than half of community-dwelling individuals sixty years and older express concern about declining cognitive abilities. The current study’s aim was to evaluate hyperbaric oxygen therapy (HBOT) effect on cognitive functions in healthy aging adults. A randomized controlled clinical trial randomize...

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Autores principales: Amir, Hadanny, Malka, Daniel-Kotovsky, Gil, Suzin, Rahav, Boussi-Gross, Merav, Catalogna, Kobi, Dagan, Yafit, Hachmo, Ramzia, Abu Hamed, Efrat, Sasson, Gregory, Fishlev, Erez, Lang, Nir, Polak, Keren, Doenyas, Mony, Friedman, Sigal, Tal, Yonatan, Zemel, Yair, Bechor, Shai, Efrati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377835/
https://www.ncbi.nlm.nih.gov/pubmed/32589613
http://dx.doi.org/10.18632/aging.103571
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author Amir, Hadanny
Malka, Daniel-Kotovsky
Gil, Suzin
Rahav, Boussi-Gross
Merav, Catalogna
Kobi, Dagan
Yafit, Hachmo
Ramzia, Abu Hamed
Efrat, Sasson
Gregory, Fishlev
Erez, Lang
Nir, Polak
Keren, Doenyas
Mony, Friedman
Sigal, Tal
Yonatan, Zemel
Yair, Bechor
Shai, Efrati
author_facet Amir, Hadanny
Malka, Daniel-Kotovsky
Gil, Suzin
Rahav, Boussi-Gross
Merav, Catalogna
Kobi, Dagan
Yafit, Hachmo
Ramzia, Abu Hamed
Efrat, Sasson
Gregory, Fishlev
Erez, Lang
Nir, Polak
Keren, Doenyas
Mony, Friedman
Sigal, Tal
Yonatan, Zemel
Yair, Bechor
Shai, Efrati
author_sort Amir, Hadanny
collection PubMed
description More than half of community-dwelling individuals sixty years and older express concern about declining cognitive abilities. The current study’s aim was to evaluate hyperbaric oxygen therapy (HBOT) effect on cognitive functions in healthy aging adults. A randomized controlled clinical trial randomized 63 healthy adults (>64) either to HBOT(n=33) or control arms(n=30) for three months. Primary endpoint included the general cognitive function measured post intervention/control. Cerebral blood flow (CBF) was evaluated by perfusion magnetic resonance imaging. There was a significant group-by-time interaction in global cognitive function post-HBOT compared to control (p=0.0017). The most striking improvements were in attention (net effect size=0.745) and information processing speed (net effect size=0.788). Voxel-based analysis showed significant cerebral blood flow increases in the HBOT group compared to the control group in the right superior medial frontal gyrus (BA10), right and left supplementary motor area (BA6), right middle frontal gyrus (BA6), left middle frontal gyrus (BA9), left superior frontal gyrus (BA8) and the right superior parietal gyrus (BA7). In this study, HBOT was shown to induce cognitive enhancements in healthy aging adults via mechanisms involving regional changes in CBF. The main improvements include attention, information processing speed and executive functions, which normally decline with aging.
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spelling pubmed-73778352020-07-31 Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial Amir, Hadanny Malka, Daniel-Kotovsky Gil, Suzin Rahav, Boussi-Gross Merav, Catalogna Kobi, Dagan Yafit, Hachmo Ramzia, Abu Hamed Efrat, Sasson Gregory, Fishlev Erez, Lang Nir, Polak Keren, Doenyas Mony, Friedman Sigal, Tal Yonatan, Zemel Yair, Bechor Shai, Efrati Aging (Albany NY) Research Paper More than half of community-dwelling individuals sixty years and older express concern about declining cognitive abilities. The current study’s aim was to evaluate hyperbaric oxygen therapy (HBOT) effect on cognitive functions in healthy aging adults. A randomized controlled clinical trial randomized 63 healthy adults (>64) either to HBOT(n=33) or control arms(n=30) for three months. Primary endpoint included the general cognitive function measured post intervention/control. Cerebral blood flow (CBF) was evaluated by perfusion magnetic resonance imaging. There was a significant group-by-time interaction in global cognitive function post-HBOT compared to control (p=0.0017). The most striking improvements were in attention (net effect size=0.745) and information processing speed (net effect size=0.788). Voxel-based analysis showed significant cerebral blood flow increases in the HBOT group compared to the control group in the right superior medial frontal gyrus (BA10), right and left supplementary motor area (BA6), right middle frontal gyrus (BA6), left middle frontal gyrus (BA9), left superior frontal gyrus (BA8) and the right superior parietal gyrus (BA7). In this study, HBOT was shown to induce cognitive enhancements in healthy aging adults via mechanisms involving regional changes in CBF. The main improvements include attention, information processing speed and executive functions, which normally decline with aging. Impact Journals 2020-06-26 /pmc/articles/PMC7377835/ /pubmed/32589613 http://dx.doi.org/10.18632/aging.103571 Text en Copyright © 2020 Amir et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Amir, Hadanny
Malka, Daniel-Kotovsky
Gil, Suzin
Rahav, Boussi-Gross
Merav, Catalogna
Kobi, Dagan
Yafit, Hachmo
Ramzia, Abu Hamed
Efrat, Sasson
Gregory, Fishlev
Erez, Lang
Nir, Polak
Keren, Doenyas
Mony, Friedman
Sigal, Tal
Yonatan, Zemel
Yair, Bechor
Shai, Efrati
Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial
title Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial
title_full Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial
title_fullStr Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial
title_full_unstemmed Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial
title_short Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial
title_sort cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377835/
https://www.ncbi.nlm.nih.gov/pubmed/32589613
http://dx.doi.org/10.18632/aging.103571
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