The Gαh/phospholipase C-δ1 interaction promotes autophagosome degradation by activating the Akt/mTORC1 pathway in metastatic triple-negative breast cancer

Lung metastasis (LM) is commonly found in triple-negative breast cancer (TNBC); however, the molecular mechanism underlying TNBC metastasis to lungs remains largely unknown. We thus aimed to uncover a possible mechanism for the LM of TNBC. Here we show that the phosphorylation of Akt and mTORC1 was...

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Detalles Bibliográficos
Autores principales: Lin, Hui-Yu, Kuei, Chia-Hao, Lee, Hsun-Hua, Lin, Che-Hsuan, Zheng, Jing-Quan, Chiu, Hui-Wen, Chen, Chi-Long, Lin, Yuan-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377847/
https://www.ncbi.nlm.nih.gov/pubmed/32615541
http://dx.doi.org/10.18632/aging.103390

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