Cargando…

Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids

The molecular basis of aging and of aging-associated diseases is being unraveled at an increasing pace. An extended healthspan, and not merely an extension of lifespan, has become the aim of medical practice. Here, we define health based on the absence of diseases and dysfunctions. Based on an exten...

Descripción completa

Detalles Bibliográficos
Autores principales: Möller, Steffen, Saul, Nadine, Cohen, Alan A., Köhling, Rüdiger, Sender, Sina, Escobar, Hugo Murua, Junghanss, Christian, Cirulli, Francesca, Berry, Alessandra, Antal, Peter, Adler, Priit, Vilo, Jaak, Boiani, Michele, Jansen, Ludger, Repsilber, Dirk, Grabe, Hans Jörgen, Struckmann, Stephan, Barrantes, Israel, Hamed, Mohamed, Wouters, Brecht, Schoofs, Liliane, Luyten, Walter, Fuellen, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377848/
https://www.ncbi.nlm.nih.gov/pubmed/32634117
http://dx.doi.org/10.18632/aging.103514
_version_ 1783562294216622080
author Möller, Steffen
Saul, Nadine
Cohen, Alan A.
Köhling, Rüdiger
Sender, Sina
Escobar, Hugo Murua
Junghanss, Christian
Cirulli, Francesca
Berry, Alessandra
Antal, Peter
Adler, Priit
Vilo, Jaak
Boiani, Michele
Jansen, Ludger
Repsilber, Dirk
Grabe, Hans Jörgen
Struckmann, Stephan
Barrantes, Israel
Hamed, Mohamed
Wouters, Brecht
Schoofs, Liliane
Luyten, Walter
Fuellen, Georg
author_facet Möller, Steffen
Saul, Nadine
Cohen, Alan A.
Köhling, Rüdiger
Sender, Sina
Escobar, Hugo Murua
Junghanss, Christian
Cirulli, Francesca
Berry, Alessandra
Antal, Peter
Adler, Priit
Vilo, Jaak
Boiani, Michele
Jansen, Ludger
Repsilber, Dirk
Grabe, Hans Jörgen
Struckmann, Stephan
Barrantes, Israel
Hamed, Mohamed
Wouters, Brecht
Schoofs, Liliane
Luyten, Walter
Fuellen, Georg
author_sort Möller, Steffen
collection PubMed
description The molecular basis of aging and of aging-associated diseases is being unraveled at an increasing pace. An extended healthspan, and not merely an extension of lifespan, has become the aim of medical practice. Here, we define health based on the absence of diseases and dysfunctions. Based on an extensive review of the literature, in particular for humans and C. elegans, we compile a list of features of health and of the genes associated with them. These genes may or may not be associated with survival/lifespan. In turn, survival/lifespan genes that are not known to be directly associated with health are not considered. Clusters of these genes based on molecular interaction data give rise to maps of healthspan pathways for humans and for C. elegans. Overlaying healthspan-related gene expression data onto the healthspan pathway maps, we observe the downregulation of (pro-inflammatory) Notch signaling in humans and of proliferation in C. elegans. We identify transcription, proliferation/biosynthesis and lipids as a common theme on the annotation level, and proliferation-related kinases on the gene/protein level. Our literature-based data corpus, including visualization, should be seen as a pilot investigation of the molecular underpinnings of health in two different species. Web address: http://pathways.h2020awe.eu.
format Online
Article
Text
id pubmed-7377848
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Impact Journals
record_format MEDLINE/PubMed
spelling pubmed-73778482020-07-31 Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids Möller, Steffen Saul, Nadine Cohen, Alan A. Köhling, Rüdiger Sender, Sina Escobar, Hugo Murua Junghanss, Christian Cirulli, Francesca Berry, Alessandra Antal, Peter Adler, Priit Vilo, Jaak Boiani, Michele Jansen, Ludger Repsilber, Dirk Grabe, Hans Jörgen Struckmann, Stephan Barrantes, Israel Hamed, Mohamed Wouters, Brecht Schoofs, Liliane Luyten, Walter Fuellen, Georg Aging (Albany NY) Research Paper The molecular basis of aging and of aging-associated diseases is being unraveled at an increasing pace. An extended healthspan, and not merely an extension of lifespan, has become the aim of medical practice. Here, we define health based on the absence of diseases and dysfunctions. Based on an extensive review of the literature, in particular for humans and C. elegans, we compile a list of features of health and of the genes associated with them. These genes may or may not be associated with survival/lifespan. In turn, survival/lifespan genes that are not known to be directly associated with health are not considered. Clusters of these genes based on molecular interaction data give rise to maps of healthspan pathways for humans and for C. elegans. Overlaying healthspan-related gene expression data onto the healthspan pathway maps, we observe the downregulation of (pro-inflammatory) Notch signaling in humans and of proliferation in C. elegans. We identify transcription, proliferation/biosynthesis and lipids as a common theme on the annotation level, and proliferation-related kinases on the gene/protein level. Our literature-based data corpus, including visualization, should be seen as a pilot investigation of the molecular underpinnings of health in two different species. Web address: http://pathways.h2020awe.eu. Impact Journals 2020-07-07 /pmc/articles/PMC7377848/ /pubmed/32634117 http://dx.doi.org/10.18632/aging.103514 Text en Copyright © 2020 Möller et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Möller, Steffen
Saul, Nadine
Cohen, Alan A.
Köhling, Rüdiger
Sender, Sina
Escobar, Hugo Murua
Junghanss, Christian
Cirulli, Francesca
Berry, Alessandra
Antal, Peter
Adler, Priit
Vilo, Jaak
Boiani, Michele
Jansen, Ludger
Repsilber, Dirk
Grabe, Hans Jörgen
Struckmann, Stephan
Barrantes, Israel
Hamed, Mohamed
Wouters, Brecht
Schoofs, Liliane
Luyten, Walter
Fuellen, Georg
Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids
title Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids
title_full Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids
title_fullStr Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids
title_full_unstemmed Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids
title_short Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids
title_sort healthspan pathway maps in c. elegans and humans highlight transcription, proliferation/biosynthesis and lipids
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377848/
https://www.ncbi.nlm.nih.gov/pubmed/32634117
http://dx.doi.org/10.18632/aging.103514
work_keys_str_mv AT mollersteffen healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT saulnadine healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT cohenalana healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT kohlingrudiger healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT sendersina healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT escobarhugomurua healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT junghansschristian healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT cirullifrancesca healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT berryalessandra healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT antalpeter healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT adlerpriit healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT vilojaak healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT boianimichele healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT jansenludger healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT repsilberdirk healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT grabehansjorgen healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT struckmannstephan healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT barrantesisrael healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT hamedmohamed healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT woutersbrecht healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT schoofsliliane healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT luytenwalter healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids
AT fuellengeorg healthspanpathwaymapsincelegansandhumanshighlighttranscriptionproliferationbiosynthesisandlipids