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Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids
The molecular basis of aging and of aging-associated diseases is being unraveled at an increasing pace. An extended healthspan, and not merely an extension of lifespan, has become the aim of medical practice. Here, we define health based on the absence of diseases and dysfunctions. Based on an exten...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377848/ https://www.ncbi.nlm.nih.gov/pubmed/32634117 http://dx.doi.org/10.18632/aging.103514 |
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author | Möller, Steffen Saul, Nadine Cohen, Alan A. Köhling, Rüdiger Sender, Sina Escobar, Hugo Murua Junghanss, Christian Cirulli, Francesca Berry, Alessandra Antal, Peter Adler, Priit Vilo, Jaak Boiani, Michele Jansen, Ludger Repsilber, Dirk Grabe, Hans Jörgen Struckmann, Stephan Barrantes, Israel Hamed, Mohamed Wouters, Brecht Schoofs, Liliane Luyten, Walter Fuellen, Georg |
author_facet | Möller, Steffen Saul, Nadine Cohen, Alan A. Köhling, Rüdiger Sender, Sina Escobar, Hugo Murua Junghanss, Christian Cirulli, Francesca Berry, Alessandra Antal, Peter Adler, Priit Vilo, Jaak Boiani, Michele Jansen, Ludger Repsilber, Dirk Grabe, Hans Jörgen Struckmann, Stephan Barrantes, Israel Hamed, Mohamed Wouters, Brecht Schoofs, Liliane Luyten, Walter Fuellen, Georg |
author_sort | Möller, Steffen |
collection | PubMed |
description | The molecular basis of aging and of aging-associated diseases is being unraveled at an increasing pace. An extended healthspan, and not merely an extension of lifespan, has become the aim of medical practice. Here, we define health based on the absence of diseases and dysfunctions. Based on an extensive review of the literature, in particular for humans and C. elegans, we compile a list of features of health and of the genes associated with them. These genes may or may not be associated with survival/lifespan. In turn, survival/lifespan genes that are not known to be directly associated with health are not considered. Clusters of these genes based on molecular interaction data give rise to maps of healthspan pathways for humans and for C. elegans. Overlaying healthspan-related gene expression data onto the healthspan pathway maps, we observe the downregulation of (pro-inflammatory) Notch signaling in humans and of proliferation in C. elegans. We identify transcription, proliferation/biosynthesis and lipids as a common theme on the annotation level, and proliferation-related kinases on the gene/protein level. Our literature-based data corpus, including visualization, should be seen as a pilot investigation of the molecular underpinnings of health in two different species. Web address: http://pathways.h2020awe.eu. |
format | Online Article Text |
id | pubmed-7377848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-73778482020-07-31 Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids Möller, Steffen Saul, Nadine Cohen, Alan A. Köhling, Rüdiger Sender, Sina Escobar, Hugo Murua Junghanss, Christian Cirulli, Francesca Berry, Alessandra Antal, Peter Adler, Priit Vilo, Jaak Boiani, Michele Jansen, Ludger Repsilber, Dirk Grabe, Hans Jörgen Struckmann, Stephan Barrantes, Israel Hamed, Mohamed Wouters, Brecht Schoofs, Liliane Luyten, Walter Fuellen, Georg Aging (Albany NY) Research Paper The molecular basis of aging and of aging-associated diseases is being unraveled at an increasing pace. An extended healthspan, and not merely an extension of lifespan, has become the aim of medical practice. Here, we define health based on the absence of diseases and dysfunctions. Based on an extensive review of the literature, in particular for humans and C. elegans, we compile a list of features of health and of the genes associated with them. These genes may or may not be associated with survival/lifespan. In turn, survival/lifespan genes that are not known to be directly associated with health are not considered. Clusters of these genes based on molecular interaction data give rise to maps of healthspan pathways for humans and for C. elegans. Overlaying healthspan-related gene expression data onto the healthspan pathway maps, we observe the downregulation of (pro-inflammatory) Notch signaling in humans and of proliferation in C. elegans. We identify transcription, proliferation/biosynthesis and lipids as a common theme on the annotation level, and proliferation-related kinases on the gene/protein level. Our literature-based data corpus, including visualization, should be seen as a pilot investigation of the molecular underpinnings of health in two different species. Web address: http://pathways.h2020awe.eu. Impact Journals 2020-07-07 /pmc/articles/PMC7377848/ /pubmed/32634117 http://dx.doi.org/10.18632/aging.103514 Text en Copyright © 2020 Möller et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Möller, Steffen Saul, Nadine Cohen, Alan A. Köhling, Rüdiger Sender, Sina Escobar, Hugo Murua Junghanss, Christian Cirulli, Francesca Berry, Alessandra Antal, Peter Adler, Priit Vilo, Jaak Boiani, Michele Jansen, Ludger Repsilber, Dirk Grabe, Hans Jörgen Struckmann, Stephan Barrantes, Israel Hamed, Mohamed Wouters, Brecht Schoofs, Liliane Luyten, Walter Fuellen, Georg Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids |
title | Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids |
title_full | Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids |
title_fullStr | Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids |
title_full_unstemmed | Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids |
title_short | Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids |
title_sort | healthspan pathway maps in c. elegans and humans highlight transcription, proliferation/biosynthesis and lipids |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377848/ https://www.ncbi.nlm.nih.gov/pubmed/32634117 http://dx.doi.org/10.18632/aging.103514 |
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