Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage

Intracerebral hemorrhage (ICH) is associated with old age and underlying conditions such as hypertension and diabetes. ICH patients are vulnerable to SARS-CoV-2 infection and develop serious complications as a result of infection. The pathophysiology of ICH patients with SARS-CoV-2 infection include...

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Autores principales: Dong, Sisi, Liu, Peipei, Luo, Yuhan, Cui, Ying, Song, Lilong, Chen, Yingzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377897/
https://www.ncbi.nlm.nih.gov/pubmed/32633728
http://dx.doi.org/10.18632/aging.103511
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author Dong, Sisi
Liu, Peipei
Luo, Yuhan
Cui, Ying
Song, Lilong
Chen, Yingzhu
author_facet Dong, Sisi
Liu, Peipei
Luo, Yuhan
Cui, Ying
Song, Lilong
Chen, Yingzhu
author_sort Dong, Sisi
collection PubMed
description Intracerebral hemorrhage (ICH) is associated with old age and underlying conditions such as hypertension and diabetes. ICH patients are vulnerable to SARS-CoV-2 infection and develop serious complications as a result of infection. The pathophysiology of ICH patients with SARS-CoV-2 infection includes viral invasion, dysfunction of the ACE2–Ang (1–7)–MasR and ACE–Ang II–AT(1)R axes, overactive immune response, cytokine storm, and excessive oxidative stress. These patients have high morbidity and mortality due to hyaline membrane formation, respiratory failure, neurologic deficits, and multiple organ failure.
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spelling pubmed-73778972020-07-31 Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage Dong, Sisi Liu, Peipei Luo, Yuhan Cui, Ying Song, Lilong Chen, Yingzhu Aging (Albany NY) Review Intracerebral hemorrhage (ICH) is associated with old age and underlying conditions such as hypertension and diabetes. ICH patients are vulnerable to SARS-CoV-2 infection and develop serious complications as a result of infection. The pathophysiology of ICH patients with SARS-CoV-2 infection includes viral invasion, dysfunction of the ACE2–Ang (1–7)–MasR and ACE–Ang II–AT(1)R axes, overactive immune response, cytokine storm, and excessive oxidative stress. These patients have high morbidity and mortality due to hyaline membrane formation, respiratory failure, neurologic deficits, and multiple organ failure. Impact Journals 2020-07-07 /pmc/articles/PMC7377897/ /pubmed/32633728 http://dx.doi.org/10.18632/aging.103511 Text en Copyright © 2020 Dong et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Dong, Sisi
Liu, Peipei
Luo, Yuhan
Cui, Ying
Song, Lilong
Chen, Yingzhu
Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage
title Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage
title_full Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage
title_fullStr Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage
title_full_unstemmed Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage
title_short Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage
title_sort pathophysiology of sars-cov-2 infection in patients with intracerebral hemorrhage
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377897/
https://www.ncbi.nlm.nih.gov/pubmed/32633728
http://dx.doi.org/10.18632/aging.103511
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